if (!require("knitr", quietly = TRUE))
install.packages("knitr")
if (!require("RSQLite", quietly = TRUE)){
install.packages("RSQLite")
}
library(knitr)
library(RSQLite)
load("A3.RData")
The ranked gene list from A2 is shown below. There are multiple parameters that can be selected. We selected to use the up-regulated rank by logFC, to keep same with the original paper. Original data GSE_150392 can be downloaded from https://www.ncbi.nlm.nih.gov/geo/query/acc.cgi?acc=GSE150392
[1]
knitr::kable(MultipuleRank, caption = 'Table 1. Ranked Gene list by logFC Up-Regulated')
| Gene | logFC | logCPM | F | PValue | FDR |
|---|---|---|---|---|---|
| PGAM2 | -5.823109 | 5.602283 | 114.57596 | 0.0000032 | 0.0012769 |
| KCNIP2 | -5.719563 | 4.086743 | 160.76552 | 0.0000007 | 0.0007268 |
| MYL2 | -5.499684 | 10.723374 | 108.19050 | 0.0000040 | 0.0012869 |
| FBXL22 | -5.289779 | 3.678330 | 113.60661 | 0.0000033 | 0.0012869 |
| ALAS2 | -5.044219 | 5.316813 | 210.75460 | 0.0000002 | 0.0007000 |
| METTL7B | -4.984911 | 3.734938 | 68.29247 | 0.0000241 | 0.0024364 |
| HHATL | -4.724839 | 4.224531 | 108.70331 | 0.0000039 | 0.0012869 |
| ACTA1 | -4.549569 | 7.045206 | 63.09443 | 0.0000326 | 0.0027663 |
| FXYD1 | -4.430060 | 5.376322 | 55.46745 | 0.0000529 | 0.0032675 |
| SPC25 | -4.366327 | 2.902875 | 43.86371 | 0.0001256 | 0.0052210 |
| FAM111B | -4.336571 | 2.874277 | 102.56547 | 0.0000044 | 0.0012883 |
| LINC02502 | -4.298162 | 2.405372 | 24.32000 | 0.0009597 | 0.0161242 |
| TNNC1 | -4.285373 | 9.436908 | 94.52402 | 0.0000068 | 0.0014874 |
| IRX4-AS1 | -4.282455 | 2.134377 | 20.00454 | 0.0017844 | 0.0229872 |
| COX6A2 | -4.168300 | 2.086863 | 25.38949 | 0.0008339 | 0.0148626 |
| PBK | -4.114213 | 3.718915 | 170.56504 | 0.0000005 | 0.0007127 |
| TCAP | -4.067439 | 6.552621 | 80.76739 | 0.0000126 | 0.0017434 |
| CENPM | -4.064744 | 3.126273 | 42.12308 | 0.0001454 | 0.0056996 |
| MSS51 | -4.049343 | 3.683218 | 103.53421 | 0.0000047 | 0.0012904 |
| TMSB15A | -4.023837 | 3.743561 | 37.09184 | 0.0002289 | 0.0074975 |
| TNMD | -4.017588 | 5.303521 | 89.96110 | 0.0000083 | 0.0015101 |
| MAOB | -4.013483 | 2.448577 | 65.21380 | 0.0000287 | 0.0026349 |
| S100A8 | -3.987699 | 1.883211 | 20.61993 | 0.0016239 | 0.0217399 |
| ADPRHL1 | -3.938632 | 5.307378 | 158.94060 | 0.0000007 | 0.0007268 |
| MYL7 | -3.935387 | 12.710147 | 65.20630 | 0.0000287 | 0.0026349 |
| ODAM | -3.875695 | 1.766859 | 30.72430 | 0.0018866 | 0.0238249 |
| CKMT2 | -3.843017 | 6.214901 | 138.62454 | 0.0000013 | 0.0008940 |
| CCDC34 | -3.807975 | 5.223245 | 66.11307 | 0.0000273 | 0.0025570 |
| TROAP | -3.795809 | 2.443732 | 84.78398 | 0.0000090 | 0.0015377 |
| FGF12 | -3.795245 | 6.805036 | 156.87407 | 0.0000007 | 0.0007268 |
| ACE2 | -3.792261 | 3.553994 | 22.73039 | 0.0011935 | 0.0182253 |
| MYL4 | -3.789321 | 10.195632 | 76.73172 | 0.0000154 | 0.0019481 |
| NME5 | -3.772923 | 2.783836 | 48.77469 | 0.0000852 | 0.0041860 |
| HSPB7 | -3.772049 | 10.052815 | 166.34553 | 0.0000006 | 0.0007127 |
| CPNE5 | -3.696151 | 5.992740 | 171.99675 | 0.0000005 | 0.0007127 |
| CORIN | -3.695186 | 6.589812 | 61.16965 | 0.0000366 | 0.0028743 |
| RAD51AP1 | -3.668636 | 2.661695 | 104.40286 | 0.0000039 | 0.0012869 |
| SUSD2 | -3.664531 | 3.047584 | 46.43830 | 0.0001020 | 0.0046244 |
| NAV2-AS2 | -3.659570 | 5.527039 | 60.34002 | 0.0000386 | 0.0029093 |
| TNNI1 | -3.649594 | 10.687197 | 83.04644 | 0.0000113 | 0.0016217 |
| GJD2 | -3.648797 | 2.004456 | 64.36838 | 0.0005406 | 0.0116472 |
| LDB3 | -3.633489 | 7.996646 | 144.52753 | 0.0000010 | 0.0008348 |
| GINS2 | -3.632645 | 3.427047 | 75.81022 | 0.0000161 | 0.0019774 |
| PCLAF | -3.618731 | 3.518891 | 31.51488 | 0.0004036 | 0.0100969 |
| MYLK-AS1 | -3.614126 | 3.636269 | 25.19938 | 0.0008547 | 0.0150415 |
| ACTC1 | -3.599775 | 13.373242 | 95.08687 | 0.0000057 | 0.0014052 |
| MIR133A1HG | -3.586468 | 3.376682 | 55.81417 | 0.0000517 | 0.0032300 |
| LINC01611 | -3.581984 | 2.196025 | 20.81456 | 0.0015769 | 0.0214442 |
| LDHD | -3.576655 | 2.728602 | 102.45834 | 0.0000042 | 0.0012883 |
| LINC01182 | -3.561014 | 2.109034 | 21.69740 | 0.0013837 | 0.0199363 |
| SLC35D3 | -3.553160 | 1.849767 | 65.26468 | 0.0019145 | 0.0240364 |
| CD36 | -3.544471 | 5.422586 | 121.37468 | 0.0000022 | 0.0011591 |
| MB | -3.542870 | 7.055788 | 97.04714 | 0.0000061 | 0.0014197 |
| MARCHF11 | -3.530975 | 3.912894 | 59.83615 | 0.0000398 | 0.0029469 |
| FABP3 | -3.492141 | 9.278923 | 59.86107 | 0.0000397 | 0.0029469 |
| TNNI3 | -3.479622 | 9.576369 | 58.99188 | 0.0000420 | 0.0030190 |
| C1QL1 | -3.445765 | 4.228980 | 53.15605 | 0.0000620 | 0.0035473 |
| MYH7 | -3.415903 | 11.653417 | 21.54393 | 0.0014151 | 0.0202251 |
| HSPB3 | -3.409678 | 6.944682 | 64.26989 | 0.0000304 | 0.0026939 |
| LMOD2 | -3.403714 | 6.089989 | 142.83660 | 0.0000011 | 0.0008348 |
| SMPX | -3.395799 | 7.962930 | 59.92075 | 0.0000396 | 0.0029469 |
| GPD1 | -3.377976 | 2.085860 | 75.09594 | 0.0005304 | 0.0115514 |
| DLGAP5 | -3.375682 | 3.879891 | 72.90729 | 0.0000187 | 0.0021763 |
| ATP6V1G2 | -3.357918 | 2.813120 | 35.17433 | 0.0002758 | 0.0083139 |
| AURKB | -3.351708 | 3.019736 | 51.41282 | 0.0000702 | 0.0037726 |
| CDKN3 | -3.334427 | 3.629323 | 39.82371 | 0.0001778 | 0.0065217 |
| CENPU | -3.303800 | 4.258795 | 114.11012 | 0.0000027 | 0.0012769 |
| TRIM54 | -3.298866 | 3.697847 | 93.65253 | 0.0000064 | 0.0014424 |
| FITM1 | -3.291142 | 6.445232 | 45.38724 | 0.0001109 | 0.0048176 |
| OIP5 | -3.282617 | 2.587212 | 64.26485 | 0.0000292 | 0.0026381 |
| FSD2 | -3.274605 | 4.403858 | 46.69062 | 0.0001000 | 0.0045547 |
| NDC80 | -3.269491 | 3.617126 | 87.75540 | 0.0000086 | 0.0015265 |
| CHCHD10 | -3.261912 | 4.051329 | 37.10621 | 0.0002286 | 0.0074975 |
| FAM133A | -3.237091 | 1.828973 | 31.89990 | 0.0035706 | 0.0351559 |
| DMAC1 | -3.234254 | 5.058723 | 50.98336 | 0.0000724 | 0.0038494 |
| KLHDC9 | -3.218902 | 2.751979 | 39.92567 | 0.0001762 | 0.0065139 |
| PPP1R1A | -3.171572 | 5.119336 | 66.15034 | 0.0000272 | 0.0025570 |
| LSMEM2 | -3.164595 | 4.363786 | 59.04122 | 0.0000419 | 0.0030190 |
| SPSB4 | -3.155675 | 3.233936 | 56.20985 | 0.0000503 | 0.0031761 |
| NUF2 | -3.151356 | 2.999939 | 89.38433 | 0.0000073 | 0.0015101 |
| TESC | -3.150083 | 4.749327 | 76.28222 | 0.0000157 | 0.0019675 |
| CALN1 | -3.145096 | 4.329778 | 45.04932 | 0.0001140 | 0.0049161 |
| PLCB2 | -3.129927 | 3.219895 | 51.74126 | 0.0000685 | 0.0037557 |
| AIF1L | -3.108962 | 6.167169 | 83.38509 | 0.0000111 | 0.0016097 |
| ITGB1BP2 | -3.103756 | 5.368974 | 86.36585 | 0.0000097 | 0.0015449 |
| PPP1R1C | -3.100553 | 3.392007 | 44.24209 | 0.0001217 | 0.0051481 |
| FGF13-AS1 | -3.097264 | 1.849855 | 30.03096 | 0.0040713 | 0.0379895 |
| SLC5A12 | -3.096242 | 2.155342 | 42.05370 | 0.0006515 | 0.0129466 |
| NPPA | -3.091703 | 12.905503 | 43.44037 | 0.0001301 | 0.0053098 |
| CDCA3 | -3.086259 | 3.713057 | 43.92216 | 0.0001250 | 0.0052069 |
| GABRA4 | -3.068427 | 3.055071 | 56.75777 | 0.0000485 | 0.0031436 |
| CAV3 | -3.066379 | 3.136842 | 54.16213 | 0.0000578 | 0.0034176 |
| KIF20A | -3.066232 | 4.724288 | 37.42469 | 0.0002218 | 0.0073503 |
| SELENOP | -3.060758 | 6.162977 | 101.98209 | 0.0000045 | 0.0012883 |
| CRYM | -3.048275 | 3.285350 | 63.43901 | 0.0000319 | 0.0027505 |
| DHFR | -3.035134 | 4.171379 | 97.32632 | 0.0000052 | 0.0013682 |
| BBOX1-AS1 | -3.034916 | 1.824077 | 29.38297 | 0.0052955 | 0.0449764 |
| ZWINT | -3.030731 | 4.480563 | 108.41300 | 0.0000034 | 0.0012869 |
| SPC24 | -3.025167 | 2.311906 | 38.16759 | 0.0002206 | 0.0073354 |
| COL9A1 | -3.024658 | 2.758275 | 46.92348 | 0.0000982 | 0.0045464 |
| PANCR | -3.015240 | 1.815120 | 14.93628 | 0.0055620 | 0.0463645 |
| NUDT7 | -3.015061 | 3.352483 | 53.07165 | 0.0000624 | 0.0035579 |
| C1orf105 | -3.013779 | 4.009494 | 32.81289 | 0.0003512 | 0.0094029 |
| HOPX | -3.009609 | 7.911857 | 53.76810 | 0.0000594 | 0.0034598 |
| TOP2A | -3.004569 | 5.879015 | 28.96886 | 0.0005376 | 0.0116181 |
| FRMD3 | -2.990653 | 5.739911 | 93.15264 | 0.0000067 | 0.0014750 |
| G0S2 | -2.979050 | 7.268480 | 56.38213 | 0.0000498 | 0.0031761 |
| LINC01405 | -2.969873 | 2.961599 | 26.87404 | 0.0006912 | 0.0134324 |
| AQP10 | -2.967106 | 3.608513 | 79.67574 | 0.0000124 | 0.0017273 |
| PTGES3L | -2.953571 | 4.445324 | 71.78529 | 0.0000199 | 0.0022436 |
| SGO1 | -2.953492 | 2.308654 | 44.24394 | 0.0002917 | 0.0085806 |
| NEIL3 | -2.948272 | 2.142895 | 30.75930 | 0.0009914 | 0.0163900 |
| HRC | -2.948080 | 5.050080 | 67.43540 | 0.0000253 | 0.0025180 |
| UBE2T | -2.922022 | 5.089443 | 52.70717 | 0.0000640 | 0.0036260 |
| RXRG | -2.913305 | 2.757656 | 58.02664 | 0.0000435 | 0.0030255 |
| NREP | -2.911058 | 9.793089 | 100.85041 | 0.0000045 | 0.0012883 |
| MCM5 | -2.908502 | 4.683402 | 83.03824 | 0.0000108 | 0.0016057 |
| C11orf52 | -2.904686 | 1.917112 | 31.22355 | 0.0040481 | 0.0378087 |
| CSRP3 | -2.882775 | 10.273352 | 52.55780 | 0.0000647 | 0.0036353 |
| LEFTY2 | -2.880727 | 6.331081 | 85.03661 | 0.0000098 | 0.0015449 |
| LGALS3 | -2.871758 | 6.964936 | 44.40718 | 0.0001201 | 0.0051121 |
| VSTM2L | -2.866543 | 4.189090 | 83.29184 | 0.0000103 | 0.0015856 |
| CRIP1 | -2.865284 | 2.788855 | 15.70018 | 0.0036869 | 0.0358349 |
| KIF2C | -2.860460 | 3.511325 | 37.99659 | 0.0002102 | 0.0071578 |
| ENPP5 | -2.856968 | 2.969325 | 62.31754 | 0.0000331 | 0.0027908 |
| NCAPH | -2.854564 | 2.669372 | 48.09446 | 0.0000897 | 0.0043060 |
| LINC01456 | -2.832459 | 2.159370 | 22.93684 | 0.0011594 | 0.0178687 |
| FMC1 | -2.830633 | 3.939974 | 14.24424 | 0.0048637 | 0.0425396 |
| HMGB2 | -2.830279 | 6.353012 | 70.47858 | 0.0000213 | 0.0023028 |
| IMMP1L | -2.829254 | 3.758604 | 27.23721 | 0.0006610 | 0.0130629 |
| EMC10 | -2.824767 | 7.218908 | 53.96630 | 0.0000586 | 0.0034433 |
| RAB9B | -2.823723 | 5.225387 | 84.33594 | 0.0000098 | 0.0015449 |
| TNNT2 | -2.820532 | 11.602913 | 85.74207 | 0.0000086 | 0.0015265 |
| ASF1B | -2.817701 | 3.439544 | 58.59071 | 0.0000431 | 0.0030190 |
| SLC38A3 | -2.806756 | 2.273880 | 56.91351 | 0.0006085 | 0.0124300 |
| SLC15A2 | -2.804699 | 3.817950 | 18.75361 | 0.0021757 | 0.0260484 |
| SRPK3 | -2.800609 | 2.518381 | 55.37483 | 0.0000997 | 0.0045547 |
| SMIM1 | -2.796013 | 2.308004 | 20.64358 | 0.0016181 | 0.0217183 |
| H4C3 | -2.794520 | 6.630227 | 31.07645 | 0.0004235 | 0.0103480 |
| CSPG5 | -2.786076 | 3.521300 | 34.54088 | 0.0002939 | 0.0086206 |
| MOG | -2.766072 | 4.236609 | 84.58887 | 0.0000092 | 0.0015377 |
| SH3BGR | -2.764689 | 7.778034 | 64.79127 | 0.0000294 | 0.0026381 |
| REC114 | -2.761811 | 1.908698 | 38.33366 | 0.0057718 | 0.0472623 |
| FPGT-TNNI3K | -2.753526 | 4.400054 | 45.86065 | 0.0001068 | 0.0047481 |
| EPN3 | -2.749571 | 2.721405 | 37.55292 | 0.0002191 | 0.0073154 |
| PIMREG | -2.749342 | 3.111311 | 29.93996 | 0.0004808 | 0.0110608 |
| NMRK2 | -2.747681 | 3.532615 | 34.16588 | 0.0003053 | 0.0087842 |
| TRDN | -2.737878 | 7.398021 | 49.95256 | 0.0000781 | 0.0039752 |
| POLE2 | -2.734335 | 2.297587 | 44.12856 | 0.0006263 | 0.0126560 |
| CDC45 | -2.726066 | 2.708403 | 75.86047 | 0.0000294 | 0.0026381 |
| DIRAS3 | -2.722534 | 5.246650 | 76.62062 | 0.0000147 | 0.0019306 |
| AMT | -2.719618 | 4.128716 | 81.19617 | 0.0000109 | 0.0016057 |
| SPX | -2.708569 | 3.364626 | 45.78802 | 0.0001074 | 0.0047481 |
| CEP55 | -2.708550 | 3.253160 | 49.05146 | 0.0000835 | 0.0041158 |
| CDCA8 | -2.698342 | 2.891869 | 74.74704 | 0.0000149 | 0.0019306 |
| PEBP4 | -2.695043 | 2.159622 | 27.51015 | 0.0016200 | 0.0217289 |
| HRH2 | -2.694184 | 4.686904 | 80.59530 | 0.0000115 | 0.0016253 |
| LINC00881 | -2.692807 | 6.336775 | 48.43943 | 0.0000874 | 0.0042358 |
| SORCS3 | -2.687721 | 2.202008 | 16.34044 | 0.0032823 | 0.0334246 |
| SMYD1 | -2.687409 | 8.634806 | 28.36640 | 0.0005770 | 0.0120621 |
| GPR22 | -2.683250 | 5.043313 | 53.23310 | 0.0000617 | 0.0035385 |
| SYNPO2L | -2.672782 | 7.679458 | 109.86419 | 0.0000032 | 0.0012769 |
| IGSF5 | -2.672417 | 1.938644 | 22.12059 | 0.0058814 | 0.0477494 |
| SPHKAP | -2.668391 | 4.785341 | 15.14208 | 0.0040910 | 0.0380828 |
| ANLN | -2.662587 | 6.618821 | 17.22171 | 0.0028113 | 0.0304452 |
| CAVIN3 | -2.661827 | 4.205267 | 34.28699 | 0.0003016 | 0.0087394 |
| CASQ2 | -2.660241 | 7.989766 | 60.47205 | 0.0000382 | 0.0029093 |
| PLAC1 | -2.658369 | 2.116653 | 36.02356 | 0.0023151 | 0.0270255 |
| MYZAP | -2.654654 | 7.178472 | 60.03675 | 0.0000393 | 0.0029433 |
| GPX3 | -2.652738 | 7.094667 | 68.89002 | 0.0000232 | 0.0023965 |
| SGCA | -2.644098 | 4.754303 | 41.16441 | 0.0001579 | 0.0060764 |
| DTL | -2.641167 | 3.591869 | 30.23422 | 0.0004651 | 0.0109002 |
| SLC27A6 | -2.640879 | 6.575514 | 54.23099 | 0.0000575 | 0.0034118 |
| PDE1A | -2.636327 | 3.385269 | 23.96150 | 0.0010071 | 0.0165225 |
| UBE2E1 | -2.633303 | 4.594498 | 69.68775 | 0.0000218 | 0.0023298 |
| TYRP1 | -2.631008 | 2.466986 | 40.73282 | 0.0002766 | 0.0083233 |
| MLIP | -2.626909 | 7.348806 | 84.30360 | 0.0000092 | 0.0015377 |
| TMEM71 | -2.625232 | 4.413872 | 97.84239 | 0.0000051 | 0.0013501 |
| C11orf71 | -2.622072 | 3.166488 | 38.02702 | 0.0002096 | 0.0071578 |
| NDUFB1 | -2.617046 | 6.337492 | 30.04038 | 0.0004754 | 0.0110002 |
| CASQ1 | -2.614019 | 4.993688 | 68.94170 | 0.0000227 | 0.0023790 |
| BIRC5 | -2.603424 | 5.104400 | 93.38285 | 0.0000061 | 0.0014197 |
| TMEM163 | -2.592041 | 3.422335 | 50.45680 | 0.0000752 | 0.0039232 |
| BRINP2 | -2.587693 | 2.272114 | 19.14654 | 0.0020422 | 0.0249842 |
| RRM2 | -2.581340 | 4.726851 | 85.00166 | 0.0000089 | 0.0015377 |
| SFRP5 | -2.580538 | 6.389999 | 94.15028 | 0.0000059 | 0.0014197 |
| GPR183 | -2.580100 | 3.926360 | 50.07615 | 0.0000774 | 0.0039749 |
| PKMYT1 | -2.575518 | 2.462613 | 23.35632 | 0.0010938 | 0.0173235 |
| ALDOC | -2.573856 | 7.391990 | 80.38366 | 0.0000112 | 0.0016097 |
| PKIA | -2.570428 | 6.340182 | 81.60448 | 0.0000105 | 0.0015867 |
| MIR1-1HG-AS1 | -2.567849 | 3.616688 | 36.81472 | 0.0002350 | 0.0075473 |
| CRABP2 | -2.565913 | 9.841161 | 55.27158 | 0.0000533 | 0.0032771 |
| SLC26A9 | -2.565358 | 3.137698 | 30.38541 | 0.0004572 | 0.0108234 |
| NEK2 | -2.561090 | 3.131411 | 65.36739 | 0.0000254 | 0.0025192 |
| TYMSOS | -2.551361 | 2.217243 | 17.47788 | 0.0026904 | 0.0297094 |
| RMI2 | -2.542336 | 3.494177 | 61.93021 | 0.0000336 | 0.0028119 |
| FERMT1 | -2.540029 | 3.767847 | 40.69317 | 0.0001646 | 0.0061634 |
| COX7C | -2.538748 | 8.321217 | 29.86352 | 0.0004850 | 0.0111182 |
| DEPDC1 | -2.538447 | 4.163804 | 87.00594 | 0.0000081 | 0.0015101 |
| CKAP2L | -2.533517 | 3.063747 | 70.12482 | 0.0000191 | 0.0021905 |
| PNMT | -2.532905 | 2.044650 | 19.91435 | 0.0046481 | 0.0413085 |
| MINCR | -2.531948 | 2.317575 | 14.95233 | 0.0042409 | 0.0388960 |
| CDK1 | -2.528634 | 4.720155 | 87.35193 | 0.0000080 | 0.0015101 |
| C11orf1 | -2.523570 | 3.699331 | 26.42569 | 0.0007309 | 0.0138976 |
| UPK1B | -2.518697 | 3.740335 | 57.65215 | 0.0000458 | 0.0030761 |
| SMIM5 | -2.507403 | 2.351641 | 28.80567 | 0.0008846 | 0.0153204 |
| GIHCG | -2.502606 | 4.070940 | 29.06195 | 0.0005318 | 0.0115694 |
| CCNB2 | -2.500282 | 3.957803 | 72.93954 | 0.0000164 | 0.0019783 |
| APOBEC2 | -2.495307 | 6.768766 | 62.32141 | 0.0000341 | 0.0028119 |
| ZNF793-AS1 | -2.482754 | 2.441286 | 21.09526 | 0.0015121 | 0.0210436 |
| ADHFE1 | -2.470553 | 4.039047 | 86.42228 | 0.0000084 | 0.0015101 |
| RPE65 | -2.467311 | 2.822103 | 66.21730 | 0.0000409 | 0.0029867 |
| PHACTR3 | -2.466546 | 2.039413 | 27.35219 | 0.0057898 | 0.0473388 |
| PRADC1 | -2.464355 | 5.446662 | 35.51929 | 0.0002665 | 0.0081854 |
| ACOT2 | -2.463990 | 5.114293 | 49.12256 | 0.0000830 | 0.0041098 |
| MTERF2 | -2.454024 | 5.093586 | 67.08827 | 0.0000241 | 0.0024364 |
| HJURP | -2.451450 | 3.224890 | 26.36827 | 0.0007362 | 0.0139381 |
| TSTD1 | -2.443933 | 4.921833 | 25.47405 | 0.0008248 | 0.0147548 |
| DUSP27 | -2.443680 | 6.220475 | 13.41977 | 0.0057387 | 0.0471570 |
| CLYBL | -2.443256 | 2.658529 | 66.05325 | 0.0001572 | 0.0060712 |
| SFRP2 | -2.438680 | 3.032048 | 47.78984 | 0.0000919 | 0.0043544 |
| LRRCC1 | -2.437214 | 2.813535 | 51.67542 | 0.0000641 | 0.0036260 |
| IDNK | -2.433926 | 2.567916 | 29.80141 | 0.0004884 | 0.0111607 |
| LINC02384 | -2.433270 | 2.453138 | 22.62358 | 0.0012116 | 0.0183854 |
| EXOC3-AS1 | -2.430176 | 2.912271 | 24.60638 | 0.0009239 | 0.0157850 |
| PHOSPHO2 | -2.427786 | 2.270983 | 20.61858 | 0.0018242 | 0.0233347 |
| KCNS2 | -2.425896 | 2.613848 | 14.64476 | 0.0044984 | 0.0403073 |
| GSG1 | -2.424480 | 3.188673 | 36.02896 | 0.0002535 | 0.0079002 |
| NUSAP1 | -2.423946 | 4.639302 | 54.63118 | 0.0000560 | 0.0033764 |
| LRRC10 | -2.418899 | 6.726833 | 76.60740 | 0.0000135 | 0.0018385 |
| TMEM141 | -2.417552 | 5.353739 | 40.87874 | 0.0001619 | 0.0061221 |
| NEBL | -2.413640 | 8.496396 | 62.65125 | 0.0000305 | 0.0026939 |
| NES | -2.412128 | 6.009236 | 83.62319 | 0.0000095 | 0.0015449 |
| TRAPPC6A | -2.409063 | 4.164939 | 26.67639 | 0.0007084 | 0.0136149 |
| SLC8A1 | -2.406968 | 7.232354 | 21.61727 | 0.0014000 | 0.0200824 |
| CENPH | -2.395725 | 3.282142 | 26.98076 | 0.0006822 | 0.0132934 |
| PHYHD1 | -2.395036 | 3.490711 | 22.24569 | 0.0012784 | 0.0189503 |
| SLC30A3 | -2.395008 | 3.500846 | 73.30616 | 0.0000160 | 0.0019774 |
| C11orf74 | -2.390511 | 5.097256 | 43.62940 | 0.0001280 | 0.0052897 |
| RCSD1 | -2.389719 | 5.725755 | 40.11165 | 0.0001733 | 0.0064524 |
| C14orf180 | -2.386624 | 3.731630 | 83.44604 | 0.0000096 | 0.0015449 |
| HSPB1 | -2.385072 | 9.805323 | 28.48780 | 0.0005688 | 0.0119630 |
| EPHX2 | -2.384289 | 3.277717 | 58.93125 | 0.0000384 | 0.0029093 |
| VIPR1 | -2.382483 | 2.895056 | 26.39228 | 0.0007340 | 0.0139155 |
| NTF4 | -2.377098 | 2.412150 | 39.50176 | 0.0009882 | 0.0163644 |
| RPA3 | -2.365246 | 4.819416 | 23.48409 | 0.0010748 | 0.0171617 |
| FN3K | -2.364778 | 2.901139 | 31.40227 | 0.0004086 | 0.0101674 |
| MRPS28 | -2.358498 | 4.865356 | 35.90387 | 0.0002567 | 0.0079818 |
| ZSCAN16-AS1 | -2.356234 | 2.830133 | 18.93723 | 0.0021120 | 0.0254701 |
| TAGLN3 | -2.354777 | 2.218534 | 23.67249 | 0.0030785 | 0.0321670 |
| UBE2C | -2.349332 | 4.367176 | 29.13546 | 0.0005273 | 0.0115222 |
| DNAAF3 | -2.348180 | 2.676828 | 34.24139 | 0.0003030 | 0.0087394 |
| HSD17B8 | -2.345639 | 2.959449 | 31.66687 | 0.0003970 | 0.0100521 |
| CRYAB | -2.344243 | 8.985251 | 28.13487 | 0.0005931 | 0.0122128 |
| TRDN-AS1 | -2.340617 | 4.534752 | 58.23960 | 0.0000430 | 0.0030190 |
| FOXM1 | -2.340321 | 3.451918 | 17.45867 | 0.0026992 | 0.0297234 |
| C17orf97 | -2.335326 | 2.570693 | 50.28160 | 0.0004459 | 0.0106832 |
| PDE6B | -2.333192 | 3.174401 | 55.87002 | 0.0000476 | 0.0031122 |
| CLIC5 | -2.332800 | 6.040528 | 28.35788 | 0.0005776 | 0.0120621 |
| TMOD1 | -2.329743 | 7.113926 | 72.72280 | 0.0000166 | 0.0019783 |
| FPGT | -2.329109 | 2.490108 | 40.10933 | 0.0008135 | 0.0146726 |
| LINC01778 | -2.327603 | 2.512025 | 22.71131 | 0.0011967 | 0.0182601 |
| LRRC52-AS1 | -2.324422 | 3.644391 | 28.82426 | 0.0005467 | 0.0116920 |
| CDCA5 | -2.322462 | 2.828126 | 58.95710 | 0.0000791 | 0.0039997 |
| TK1 | -2.320187 | 4.733006 | 44.87929 | 0.0001156 | 0.0049515 |
| MORN2 | -2.319151 | 4.207714 | 23.49178 | 0.0010736 | 0.0171617 |
| GP1BB | -2.314509 | 2.952443 | 15.63393 | 0.0037322 | 0.0360061 |
| ATP5PF | -2.312218 | 8.040040 | 26.06763 | 0.0007646 | 0.0142109 |
| COL21A1 | -2.309664 | 4.739278 | 60.83793 | 0.0000352 | 0.0028119 |
| DRD1 | -2.305130 | 2.545329 | 14.66026 | 0.0044850 | 0.0402249 |
| ACSM5 | -2.303018 | 2.385382 | 53.88208 | 0.0015739 | 0.0214354 |
| NDUFA3 | -2.302154 | 6.004117 | 19.42939 | 0.0019524 | 0.0243560 |
| BOLA1 | -2.296717 | 3.132734 | 18.12030 | 0.0024143 | 0.0277539 |
| CCND2-AS1 | -2.295584 | 2.929593 | 16.76507 | 0.0030441 | 0.0319432 |
| BIK | -2.292042 | 4.562095 | 23.07729 | 0.0011369 | 0.0177094 |
| CORO6 | -2.289832 | 6.372772 | 66.69967 | 0.0000232 | 0.0023965 |
| S100A6 | -2.287949 | 4.171578 | 18.35223 | 0.0023233 | 0.0270728 |
| HAND1 | -2.281999 | 4.021494 | 50.06068 | 0.0000774 | 0.0039749 |
| KIAA0319 | -2.281731 | 2.523846 | 13.55462 | 0.0055830 | 0.0464215 |
| COX7B | -2.281664 | 7.853033 | 24.18374 | 0.0009774 | 0.0162955 |
| CRIP2 | -2.272728 | 9.555222 | 34.10054 | 0.0003073 | 0.0088094 |
| CAMK2A | -2.271184 | 2.230374 | 45.24312 | 0.0039582 | 0.0372525 |
| TECRL | -2.264283 | 7.866569 | 48.02889 | 0.0000902 | 0.0043066 |
| ACOT1 | -2.259996 | 2.526954 | 43.28432 | 0.0007880 | 0.0143980 |
| HAND2 | -2.255680 | 5.989330 | 42.70144 | 0.0001384 | 0.0055198 |
| DERL3 | -2.255450 | 2.906581 | 31.94353 | 0.0003853 | 0.0098337 |
| BANCR | -2.253846 | 6.871978 | 31.61210 | 0.0003994 | 0.0100730 |
| NIPSNAP3B | -2.253375 | 3.162935 | 39.37680 | 0.0001851 | 0.0067394 |
| LYRM9 | -2.250067 | 2.882413 | 33.06088 | 0.0003422 | 0.0093395 |
| SRP14-AS1 | -2.245190 | 3.680198 | 36.17603 | 0.0002499 | 0.0078599 |
| BCL2A1 | -2.242443 | 2.254108 | 14.98819 | 0.0042120 | 0.0387554 |
| UNC45B | -2.241744 | 8.454851 | 18.61016 | 0.0022271 | 0.0264539 |
| CTF1 | -2.240603 | 3.827212 | 30.40420 | 0.0004563 | 0.0108137 |
| ANKRD1 | -2.238789 | 9.282733 | 24.45587 | 0.0009425 | 0.0159288 |
| KIF22 | -2.232446 | 4.345682 | 70.54815 | 0.0000186 | 0.0021763 |
| YPEL1 | -2.232118 | 4.170625 | 67.48255 | 0.0000222 | 0.0023479 |
| LYPD6 | -2.228899 | 2.397693 | 15.38210 | 0.0039108 | 0.0369840 |
| TBX20 | -2.225745 | 3.898102 | 56.62588 | 0.0000455 | 0.0030701 |
| SCHIP1 | -2.222649 | 5.878322 | 71.90855 | 0.0000173 | 0.0020453 |
| SLC2A8 | -2.222631 | 4.835923 | 57.00676 | 0.0000451 | 0.0030518 |
| PLK4 | -2.221475 | 2.626243 | 16.41406 | 0.0032394 | 0.0331622 |
| SYNJ2BP-COX16 | -2.221443 | 3.773208 | 32.91179 | 0.0003476 | 0.0093542 |
| CDC6 | -2.216078 | 3.672923 | 21.20415 | 0.0014878 | 0.0208241 |
| KCNQ2 | -2.214763 | 3.048884 | 26.12628 | 0.0007590 | 0.0141490 |
| GON7 | -2.209077 | 3.519188 | 23.17055 | 0.0011223 | 0.0175621 |
| ACAT1 | -2.204879 | 6.880535 | 69.95317 | 0.0000193 | 0.0021988 |
| VSNL1 | -2.201836 | 4.885539 | 56.22627 | 0.0000475 | 0.0031122 |
| CDC20 | -2.200800 | 3.810945 | 61.78922 | 0.0000312 | 0.0027335 |
| ACADSB | -2.198825 | 4.134325 | 16.78102 | 0.0030355 | 0.0318708 |
| SELENOW | -2.198793 | 9.304079 | 29.34283 | 0.0005148 | 0.0113764 |
| LINC00526 | -2.197931 | 2.732049 | 16.93661 | 0.0029539 | 0.0312987 |
| COX6C | -2.195835 | 8.360781 | 23.13352 | 0.0011281 | 0.0176244 |
| REXO5 | -2.195596 | 3.426408 | 20.84830 | 0.0015689 | 0.0214354 |
| SSPN | -2.183134 | 4.659579 | 27.07836 | 0.0006740 | 0.0131871 |
| DAND5 | -2.181966 | 2.602316 | 24.45002 | 0.0009432 | 0.0159288 |
| RBMS3-AS3 | -2.180075 | 2.357659 | 22.80648 | 0.0026288 | 0.0293933 |
| HMGCLL1 | -2.178475 | 3.329774 | 63.32700 | 0.0000284 | 0.0026266 |
| LINC00880 | -2.177140 | 4.941708 | 58.97843 | 0.0000377 | 0.0029093 |
| C10orf71 | -2.176344 | 2.517078 | 13.39051 | 0.0057732 | 0.0472623 |
| HMGN2 | -2.174406 | 7.534315 | 37.74387 | 0.0002152 | 0.0072678 |
| MYL9 | -2.170793 | 9.804863 | 43.82020 | 0.0001213 | 0.0051481 |
| ROGDI | -2.167941 | 5.631528 | 44.24487 | 0.0001217 | 0.0051481 |
| PLN | -2.167092 | 10.586009 | 32.98622 | 0.0003449 | 0.0093542 |
| HAND2-AS1 | -2.167011 | 5.831762 | 64.36575 | 0.0000266 | 0.0025505 |
| PCBD1 | -2.167003 | 5.394227 | 27.40924 | 0.0006473 | 0.0128954 |
| MPC1 | -2.165892 | 6.005173 | 24.23629 | 0.0009706 | 0.0162227 |
| TAFA2 | -2.164442 | 2.255294 | 24.39671 | 0.0050199 | 0.0433758 |
| DNAJC28 | -2.164137 | 2.445701 | 24.11364 | 0.0017714 | 0.0228985 |
| INKA2 | -2.162963 | 4.047909 | 45.79497 | 0.0001074 | 0.0047481 |
| USH1C | -2.162887 | 2.287685 | 20.73651 | 0.0042933 | 0.0391865 |
| NDUFS6 | -2.162245 | 6.404731 | 29.01831 | 0.0005345 | 0.0115897 |
| ADCY5 | -2.158902 | 6.403468 | 18.51693 | 0.0022613 | 0.0265902 |
| MDP1 | -2.154549 | 4.111410 | 26.29860 | 0.0007426 | 0.0139891 |
| PMEL | -2.153426 | 3.412220 | 49.85708 | 0.0000736 | 0.0038614 |
| MTURN | -2.152774 | 4.617683 | 56.33443 | 0.0000460 | 0.0030777 |
| LINC01351 | -2.148929 | 2.241988 | 28.24087 | 0.0052656 | 0.0448276 |
| LINC02762 | -2.143704 | 4.734591 | 28.17354 | 0.0005904 | 0.0121937 |
| ULK4 | -2.138354 | 3.556534 | 52.49176 | 0.0000597 | 0.0034670 |
| DLGAP1-AS1 | -2.134387 | 2.569413 | 15.58070 | 0.0037691 | 0.0361948 |
| DES | -2.134094 | 7.311249 | 53.44978 | 0.0000559 | 0.0033764 |
| TMEM97 | -2.134051 | 4.002616 | 64.21022 | 0.0000269 | 0.0025570 |
| SLC5A1 | -2.133719 | 4.807662 | 18.20450 | 0.0023808 | 0.0275223 |
| PRC1 | -2.133292 | 4.849762 | 29.60058 | 0.0004998 | 0.0112467 |
| DECR1 | -2.132021 | 6.754908 | 53.62447 | 0.0000559 | 0.0033764 |
| GLIDR | -2.130896 | 3.395435 | 38.39637 | 0.0002025 | 0.0070229 |
| HMGN5 | -2.130325 | 2.776836 | 22.89057 | 0.0011669 | 0.0178976 |
| SHCBP1 | -2.129381 | 3.220118 | 17.35530 | 0.0027474 | 0.0300854 |
| ATP5ME | -2.123243 | 6.673001 | 20.47854 | 0.0016591 | 0.0220280 |
| SYNM | -2.122636 | 5.032839 | 14.79312 | 0.0043718 | 0.0395976 |
| UQCRQ | -2.122164 | 8.188141 | 23.99711 | 0.0010023 | 0.0164998 |
| NDUFB2 | -2.118844 | 7.042373 | 23.87766 | 0.0010186 | 0.0166153 |
| CMC4 | -2.118674 | 4.267070 | 25.08004 | 0.0008681 | 0.0151960 |
| ITM2A | -2.118308 | 3.567860 | 27.99204 | 0.0006033 | 0.0123602 |
| BEX2 | -2.111248 | 4.212815 | 32.95306 | 0.0003461 | 0.0093542 |
| MGST3 | -2.109753 | 8.346264 | 21.65019 | 0.0013933 | 0.0200007 |
| ANAPC16 | -2.104280 | 7.102962 | 35.44008 | 0.0002686 | 0.0082305 |
| MRPL53 | -2.101326 | 5.157360 | 19.83226 | 0.0018327 | 0.0233988 |
| NAP1L3 | -2.099201 | 5.370958 | 37.98851 | 0.0002103 | 0.0071578 |
| IL20RA | -2.099056 | 2.714177 | 36.71103 | 0.0005470 | 0.0116920 |
| ATP5MC3 | -2.098677 | 8.587440 | 29.02713 | 0.0005340 | 0.0115897 |
| GUCY1A1 | -2.098464 | 8.470145 | 45.22582 | 0.0001080 | 0.0047643 |
| MYBPC3 | -2.098119 | 8.888559 | 15.80577 | 0.0036160 | 0.0353217 |
| CDKN2C | -2.096007 | 2.806192 | 27.16126 | 0.0006672 | 0.0130934 |
| KLHL3 | -2.095120 | 5.065742 | 21.68043 | 0.0013872 | 0.0199564 |
| EFCAB7 | -2.091420 | 3.359217 | 50.90181 | 0.0000656 | 0.0036581 |
| GTSE1 | -2.089318 | 2.842977 | 45.09877 | 0.0002398 | 0.0076380 |
| ASB2 | -2.088868 | 6.945506 | 37.00136 | 0.0002308 | 0.0075122 |
| EMP2 | -2.088006 | 6.850257 | 31.32778 | 0.0004119 | 0.0101815 |
| GNG7 | -2.087833 | 3.678315 | 64.54015 | 0.0000264 | 0.0025481 |
| DOK7 | -2.086878 | 4.289914 | 73.31434 | 0.0000160 | 0.0019774 |
| PHACTR1 | -2.086106 | 4.967612 | 49.77250 | 0.0000759 | 0.0039278 |
| PLPP7 | -2.082147 | 5.797028 | 56.29100 | 0.0000446 | 0.0030414 |
| FAM229B | -2.080910 | 5.638910 | 32.65186 | 0.0003573 | 0.0094353 |
| CDCA7 | -2.075812 | 2.507710 | 19.71112 | 0.0020206 | 0.0248592 |
| HIGD2A | -2.075338 | 6.919949 | 18.70036 | 0.0021946 | 0.0261471 |
| ICA1 | -2.073635 | 4.836517 | 68.83267 | 0.0000205 | 0.0022828 |
| ATP5PD | -2.070352 | 7.400018 | 25.90665 | 0.0007804 | 0.0143064 |
| PARP1 | -2.069997 | 7.027387 | 33.84833 | 0.0003154 | 0.0088535 |
| TMEM144 | -2.068687 | 3.363263 | 57.90221 | 0.0000401 | 0.0029548 |
| SH3RF2 | -2.067586 | 4.951165 | 51.65734 | 0.0000642 | 0.0036260 |
| DGCR6 | -2.064497 | 4.510378 | 28.97295 | 0.0005373 | 0.0116181 |
| NDUFC1 | -2.062849 | 6.706193 | 19.79048 | 0.0018447 | 0.0234906 |
| ACYP1 | -2.061079 | 3.705755 | 16.05494 | 0.0034555 | 0.0345052 |
| COX8A | -2.061003 | 7.174523 | 18.02479 | 0.0024531 | 0.0280842 |
| MYLK | -2.060309 | 9.251826 | 39.45907 | 0.0001812 | 0.0066224 |
| FAM20A | -2.059499 | 2.536403 | 23.34206 | 0.0016766 | 0.0222278 |
| PLCXD3 | -2.058581 | 4.883096 | 45.79334 | 0.0001064 | 0.0047457 |
| ABHD11 | -2.056984 | 3.790402 | 36.09377 | 0.0002519 | 0.0078889 |
| MMP15 | -2.056655 | 6.566182 | 23.07605 | 0.0011371 | 0.0177094 |
| ST7-AS1 | -2.056492 | 2.512928 | 37.15366 | 0.0019371 | 0.0241803 |
| NSMCE4A | -2.054613 | 5.063454 | 55.80641 | 0.0000461 | 0.0030777 |
| INKA2-AS1 | -2.054012 | 2.680850 | 43.39229 | 0.0007955 | 0.0144810 |
| NEXN | -2.052929 | 7.854613 | 26.66831 | 0.0007091 | 0.0136149 |
| ATP5MF | -2.049363 | 6.800521 | 20.18405 | 0.0017356 | 0.0225697 |
| PPP1R14C | -2.047443 | 7.214625 | 47.84907 | 0.0000868 | 0.0042247 |
| NIFK-AS1 | -2.046841 | 2.901511 | 41.10360 | 0.0002045 | 0.0070518 |
| ERH | -2.046144 | 6.396813 | 26.20089 | 0.0007518 | 0.0140776 |
| HACD1 | -2.043966 | 7.480174 | 26.17384 | 0.0007544 | 0.0140989 |
| PET100 | -2.043188 | 5.273546 | 19.17708 | 0.0020323 | 0.0249403 |
| SMDT1 | -2.037491 | 5.542199 | 24.53255 | 0.0009330 | 0.0158372 |
| RDH5 | -2.037272 | 3.028846 | 23.52853 | 0.0010683 | 0.0171617 |
| DNAJC15 | -2.036522 | 4.760353 | 33.85317 | 0.0003152 | 0.0088535 |
| PIFO | -2.030697 | 3.565426 | 34.43401 | 0.0002971 | 0.0086644 |
| ETFRF1 | -2.029499 | 4.676854 | 20.12125 | 0.0017525 | 0.0226838 |
| SKA3 | -2.028284 | 2.472653 | 24.59829 | 0.0028315 | 0.0305793 |
| GJA5 | -2.025339 | 5.790669 | 22.33501 | 0.0012622 | 0.0188791 |
| DHRS11 | -2.024969 | 2.355453 | 31.98705 | 0.0046921 | 0.0415305 |
| GSTM4 | -2.024015 | 5.693714 | 36.46172 | 0.0002431 | 0.0077321 |
| ATP5MC1 | -2.023177 | 6.647563 | 21.24909 | 0.0014779 | 0.0207022 |
| MYL3 | -2.022303 | 8.201414 | 31.77318 | 0.0003925 | 0.0099627 |
| TIMM8B | -2.021806 | 5.967973 | 25.75849 | 0.0007953 | 0.0144810 |
| ATP5MPL | -2.020557 | 7.320474 | 20.41067 | 0.0016764 | 0.0222278 |
| CHCHD5 | -2.019536 | 3.888336 | 17.55777 | 0.0026540 | 0.0295236 |
| IL17B | -2.019427 | 2.383419 | 20.90870 | 0.0041069 | 0.0381662 |
| PPP1R3C | -2.018053 | 4.783392 | 29.60422 | 0.0004996 | 0.0112467 |
| SVIP | -2.011910 | 3.910878 | 16.67467 | 0.0030929 | 0.0322491 |
| HADH | -2.010848 | 5.595895 | 68.67077 | 0.0000207 | 0.0022838 |
| UQCR10 | -2.010785 | 7.642238 | 20.76159 | 0.0015895 | 0.0215560 |
| CHURC1-FNTB | -2.009534 | 3.707609 | 30.17326 | 0.0004683 | 0.0109265 |
| FANCL | -2.006840 | 4.456246 | 56.40377 | 0.0000443 | 0.0030414 |
| CPVL | -2.005104 | 6.774119 | 60.13375 | 0.0000346 | 0.0028119 |
| PLK1 | -2.000453 | 3.879544 | 55.08925 | 0.0000484 | 0.0031436 |
| ACOT13 | -2.000114 | 5.847783 | 30.46547 | 0.0004532 | 0.0107527 |
| PTBP3 | 2.004432 | 5.518912 | 29.26607 | 0.0005194 | 0.0114385 |
| TGFBI | 2.008175 | 8.222606 | 22.90922 | 0.0011639 | 0.0178976 |
| RLF | 2.009219 | 6.916310 | 24.51223 | 0.0009355 | 0.0158515 |
| ERO1A | 2.009337 | 6.150180 | 39.92083 | 0.0001763 | 0.0065139 |
| MYD88 | 2.019954 | 5.073590 | 30.86736 | 0.0004333 | 0.0104852 |
| LRIG3 | 2.022030 | 4.074215 | 23.79939 | 0.0010295 | 0.0167509 |
| GTF2IRD1 | 2.022119 | 5.320018 | 40.71978 | 0.0001642 | 0.0061607 |
| PIM3 | 2.022238 | 5.524202 | 64.94521 | 0.0000257 | 0.0025377 |
| RSRC2 | 2.024864 | 7.386379 | 58.53508 | 0.0000384 | 0.0029093 |
| PIGA | 2.025300 | 4.525591 | 33.41666 | 0.0003297 | 0.0091468 |
| ARRDC2 | 2.028687 | 2.975729 | 46.06784 | 0.0001172 | 0.0050104 |
| CASP4 | 2.031420 | 4.582159 | 45.33682 | 0.0001110 | 0.0048176 |
| KCNE4 | 2.032976 | 5.291654 | 43.40793 | 0.0001304 | 0.0053098 |
| TLE1 | 2.036129 | 5.850678 | 32.45804 | 0.0003647 | 0.0095666 |
| EGR1 | 2.037634 | 7.201431 | 39.15933 | 0.0001888 | 0.0068231 |
| HRH1 | 2.039099 | 4.520897 | 66.50932 | 0.0000235 | 0.0024106 |
| EVC2 | 2.040074 | 3.251847 | 28.55813 | 0.0005641 | 0.0118834 |
| H2BC5 | 2.042077 | 3.796569 | 33.39466 | 0.0003305 | 0.0091468 |
| LIPG | 2.043150 | 3.120983 | 30.06482 | 0.0004741 | 0.0110002 |
| EMP1 | 2.044095 | 3.812334 | 38.37499 | 0.0002029 | 0.0070229 |
| HAPLN3 | 2.047483 | 4.194068 | 74.36986 | 0.0000152 | 0.0019319 |
| PIK3CD | 2.048266 | 3.513463 | 26.05156 | 0.0007662 | 0.0142109 |
| DBP | 2.048628 | 4.124211 | 59.13743 | 0.0000369 | 0.0028841 |
| ADM2 | 2.052314 | 3.681901 | 35.21260 | 0.0002748 | 0.0083105 |
| BAIAP2L1 | 2.054319 | 3.244316 | 25.61844 | 0.0008097 | 0.0146300 |
| PFKFB3 | 2.054620 | 6.220168 | 15.56250 | 0.0037818 | 0.0362354 |
| TRIM22 | 2.055730 | 6.297457 | 25.72451 | 0.0007987 | 0.0145127 |
| PDZD2 | 2.058617 | 3.287078 | 41.29298 | 0.0001562 | 0.0060442 |
| ZNF844 | 2.061578 | 3.110554 | 21.42606 | 0.0014398 | 0.0205036 |
| ITGA2 | 2.062052 | 5.779381 | 36.02532 | 0.0002536 | 0.0079002 |
| DOK5 | 2.067119 | 4.379998 | 72.74209 | 0.0000165 | 0.0019783 |
| SKIL | 2.067251 | 6.890339 | 71.06788 | 0.0000181 | 0.0021288 |
| PCSK9 | 2.069441 | 2.878845 | 35.17666 | 0.0002758 | 0.0083139 |
| RAPGEF2 | 2.072268 | 6.336223 | 37.49660 | 0.0002202 | 0.0073354 |
| NPIPB15 | 2.073422 | 2.578592 | 24.83420 | 0.0011091 | 0.0174534 |
| CLCF1 | 2.075358 | 2.714797 | 34.93737 | 0.0004695 | 0.0109413 |
| RGS16 | 2.075771 | 2.246447 | 14.59476 | 0.0056342 | 0.0465904 |
| ADCY7 | 2.076348 | 3.765286 | 32.91226 | 0.0003476 | 0.0093542 |
| KLF9 | 2.079559 | 2.831800 | 31.39751 | 0.0004088 | 0.0101674 |
| SQSTM1 | 2.082316 | 10.098863 | 57.79548 | 0.0000403 | 0.0029646 |
| FGF7 | 2.083364 | 5.050689 | 46.79790 | 0.0000988 | 0.0045511 |
| SH3RF1 | 2.084813 | 6.094909 | 27.20199 | 0.0006639 | 0.0130802 |
| CDH6 | 2.086026 | 3.842225 | 55.08953 | 0.0000487 | 0.0031438 |
| HOXA-AS2 | 2.088457 | 3.095199 | 35.63492 | 0.0002635 | 0.0081436 |
| NBPF14 | 2.093447 | 5.379842 | 64.62730 | 0.0000262 | 0.0025480 |
| UBASH3B | 2.093595 | 3.201016 | 39.89774 | 0.0001766 | 0.0065151 |
| ZNF317 | 2.095386 | 6.258907 | 18.24073 | 0.0023665 | 0.0274296 |
| IFRD1 | 2.095692 | 6.835812 | 61.33781 | 0.0000321 | 0.0027505 |
| PDE7A | 2.096324 | 5.599562 | 37.26773 | 0.0002251 | 0.0074103 |
| TMEM87B | 2.099924 | 5.543321 | 38.74301 | 0.0001961 | 0.0069235 |
| DPP4 | 2.104114 | 3.978669 | 21.26956 | 0.0014735 | 0.0207016 |
| C1QTNF1 | 2.109298 | 4.248291 | 43.41985 | 0.0001303 | 0.0053098 |
| MVP | 2.111094 | 6.994655 | 42.08814 | 0.0001458 | 0.0056996 |
| ERRFI1 | 2.113944 | 7.003143 | 24.13875 | 0.0009833 | 0.0163127 |
| KLF11 | 2.114600 | 5.413462 | 17.94407 | 0.0024864 | 0.0283832 |
| NRG3 | 2.120995 | 3.509814 | 54.36167 | 0.0000514 | 0.0032300 |
| SLC38A5 | 2.122949 | 2.645344 | 36.38028 | 0.0005832 | 0.0120940 |
| ARHGAP20 | 2.123484 | 2.634645 | 24.11675 | 0.0009863 | 0.0163457 |
| THSD1 | 2.128001 | 2.363420 | 20.24808 | 0.0027872 | 0.0302996 |
| IL33 | 2.129479 | 5.178257 | 68.35190 | 0.0000211 | 0.0022998 |
| TENT5C | 2.132303 | 3.190938 | 24.57125 | 0.0009282 | 0.0158242 |
| RXFP1 | 2.133374 | 2.598005 | 17.13141 | 0.0028556 | 0.0307207 |
| NBPF26 | 2.135125 | 5.269142 | 26.29526 | 0.0007430 | 0.0139891 |
| THY1 | 2.139841 | 7.881571 | 48.91955 | 0.0000806 | 0.0040457 |
| TYMP | 2.142315 | 3.825328 | 27.48119 | 0.0006417 | 0.0128615 |
| GBP3 | 2.142594 | 4.570524 | 26.94510 | 0.0006852 | 0.0133387 |
| STARD13 | 2.146103 | 5.337618 | 26.34210 | 0.0007386 | 0.0139479 |
| LDB2 | 2.155333 | 4.882540 | 55.32438 | 0.0000501 | 0.0031761 |
| EIF2AK2 | 2.155542 | 6.387405 | 27.20722 | 0.0006635 | 0.0130802 |
| HS6ST2 | 2.158807 | 2.247820 | 20.55080 | 0.0043804 | 0.0395997 |
| ZBTB10 | 2.166943 | 5.196433 | 23.02788 | 0.0011448 | 0.0177862 |
| CHD1 | 2.167425 | 6.450497 | 49.55368 | 0.0000799 | 0.0040307 |
| GADD45B | 2.169566 | 7.554465 | 59.97477 | 0.0000350 | 0.0028119 |
| NFKBID | 2.170539 | 2.547989 | 52.98504 | 0.0008309 | 0.0148364 |
| SEC24A | 2.171192 | 6.533926 | 13.53523 | 0.0056050 | 0.0465458 |
| HFE | 2.173138 | 2.553298 | 44.69194 | 0.0008030 | 0.0145489 |
| KCNAB1 | 2.174609 | 3.216456 | 68.84353 | 0.0000205 | 0.0022828 |
| SEL1L3 | 2.178554 | 6.491276 | 17.09245 | 0.0028749 | 0.0308611 |
| LRRC8E | 2.181391 | 2.746993 | 21.81094 | 0.0013611 | 0.0197421 |
| PTGIS | 2.183773 | 8.541022 | 45.82255 | 0.0001059 | 0.0047334 |
| ACHE | 2.184265 | 4.274795 | 76.04896 | 0.0000139 | 0.0018792 |
| NEDD9 | 2.198391 | 7.346351 | 22.41278 | 0.0012483 | 0.0187707 |
| TBC1D2 | 2.199856 | 2.787065 | 31.87433 | 0.0003882 | 0.0098882 |
| IL1RL1 | 2.200511 | 7.940512 | 39.48969 | 0.0001832 | 0.0066833 |
| ATP8B1 | 2.201638 | 4.908575 | 24.29311 | 0.0009632 | 0.0161408 |
| SMURF1 | 2.206765 | 6.367100 | 14.95457 | 0.0042391 | 0.0388960 |
| CACTIN | 2.216597 | 5.371437 | 35.65443 | 0.0002630 | 0.0081408 |
| WAKMAR2 | 2.221539 | 2.255501 | 35.50517 | 0.0033638 | 0.0340250 |
| GPBP1 | 2.221672 | 7.846399 | 45.51049 | 0.0001098 | 0.0048017 |
| SNAPC1 | 2.224079 | 6.031346 | 74.62952 | 0.0000150 | 0.0019306 |
| CLK4 | 2.230614 | 5.934948 | 46.22436 | 0.0001038 | 0.0046814 |
| MFAP3L | 2.230693 | 3.271002 | 25.00516 | 0.0008766 | 0.0152898 |
| SPRED3 | 2.232555 | 2.258711 | 31.46815 | 0.0032174 | 0.0330170 |
| FOXN2 | 2.235189 | 4.821019 | 38.30894 | 0.0002041 | 0.0070518 |
| SMOX | 2.238389 | 4.386918 | 63.07335 | 0.0000291 | 0.0026381 |
| DTX3L | 2.238600 | 4.502182 | 39.29451 | 0.0001865 | 0.0067647 |
| TNFAIP2 | 2.246920 | 2.435379 | 31.99143 | 0.0011633 | 0.0178976 |
| DUSP6 | 2.247526 | 6.615571 | 59.10035 | 0.0000387 | 0.0029093 |
| ETV4 | 2.255293 | 3.389742 | 51.16339 | 0.0000698 | 0.0037609 |
| DRAM1 | 2.255817 | 5.547865 | 49.94757 | 0.0000781 | 0.0039752 |
| RASGRF2 | 2.257768 | 3.281691 | 27.15870 | 0.0006674 | 0.0130934 |
| ARSI | 2.258777 | 3.445717 | 57.34857 | 0.0000428 | 0.0030190 |
| SLC7A5 | 2.268056 | 8.820527 | 25.50067 | 0.0008220 | 0.0147311 |
| SPRED1 | 2.268266 | 5.631474 | 32.44575 | 0.0003652 | 0.0095666 |
| STEAP1 | 2.269506 | 2.158776 | 34.45582 | 0.0046983 | 0.0415667 |
| HES1 | 2.272304 | 6.315384 | 48.47497 | 0.0000872 | 0.0042349 |
| RBM15 | 2.273480 | 4.733079 | 22.39799 | 0.0012509 | 0.0187947 |
| ITGA4 | 2.280581 | 7.210732 | 23.24107 | 0.0011114 | 0.0174687 |
| DDIT3 | 2.282792 | 6.698829 | 47.72524 | 0.0000923 | 0.0043655 |
| GPR176 | 2.287500 | 6.829438 | 25.25024 | 0.0008491 | 0.0150044 |
| BRPF1 | 2.289519 | 5.016377 | 18.25805 | 0.0023597 | 0.0273672 |
| SERPINB8 | 2.291079 | 4.970055 | 82.51326 | 0.0000101 | 0.0015540 |
| DUSP1 | 2.292234 | 8.485314 | 75.91168 | 0.0000140 | 0.0018797 |
| TRIM25 | 2.294127 | 4.596770 | 23.47330 | 0.0010764 | 0.0171659 |
| CFB | 2.294208 | 3.185792 | 21.59213 | 0.0014052 | 0.0201416 |
| ALDH1A3 | 2.304578 | 5.569875 | 17.07360 | 0.0028843 | 0.0309039 |
| HTR7 | 2.306582 | 3.975230 | 29.33506 | 0.0005153 | 0.0113764 |
| SULF1 | 2.309025 | 10.514876 | 14.30185 | 0.0048089 | 0.0422406 |
| SLC2A9 | 2.313958 | 2.664464 | 51.53580 | 0.0002084 | 0.0071561 |
| TAP1 | 2.318335 | 6.931737 | 27.26981 | 0.0006584 | 0.0130241 |
| PDK4 | 2.321624 | 4.492490 | 56.64808 | 0.0000484 | 0.0031436 |
| EPHA2 | 2.323694 | 7.567711 | 27.87603 | 0.0006118 | 0.0124792 |
| SLC43A3 | 2.324096 | 3.546745 | 51.56179 | 0.0000694 | 0.0037609 |
| SLC22A3 | 2.328724 | 4.729065 | 37.98477 | 0.0002104 | 0.0071578 |
| IRAK2 | 2.332145 | 2.903430 | 52.71759 | 0.0000589 | 0.0034522 |
| TRIM38 | 2.333957 | 4.789839 | 61.01720 | 0.0000353 | 0.0028119 |
| INTS6 | 2.335218 | 6.513688 | 36.35409 | 0.0002457 | 0.0077752 |
| CD44 | 2.340378 | 7.554509 | 45.66604 | 0.0001085 | 0.0047730 |
| ELF3 | 2.340595 | 4.964933 | 84.78612 | 0.0000090 | 0.0015377 |
| BCL3 | 2.352478 | 5.600504 | 65.95346 | 0.0000252 | 0.0025180 |
| BCAR3 | 2.356021 | 5.790211 | 38.71697 | 0.0001966 | 0.0069261 |
| ULBP2 | 2.358103 | 3.957069 | 80.46097 | 0.0000111 | 0.0016097 |
| JUN | 2.358727 | 8.861739 | 32.15737 | 0.0003766 | 0.0097804 |
| MCTP2 | 2.360615 | 3.508561 | 32.70630 | 0.0003552 | 0.0094353 |
| LSMEM1 | 2.361432 | 2.317843 | 45.62247 | 0.0015010 | 0.0209329 |
| AMIGO2 | 2.368723 | 8.003288 | 43.69275 | 0.0001274 | 0.0052731 |
| ADAM32 | 2.376574 | 2.341232 | 46.01163 | 0.0012660 | 0.0189031 |
| APOL1 | 2.379876 | 4.122219 | 21.56230 | 0.0014113 | 0.0201856 |
| IRF1 | 2.379943 | 4.992209 | 87.12418 | 0.0000081 | 0.0015101 |
| INHBA | 2.383219 | 8.306131 | 78.67403 | 0.0000121 | 0.0017024 |
| MALL | 2.383326 | 2.659139 | 41.05437 | 0.0001594 | 0.0060992 |
| FRMD6 | 2.387872 | 6.891291 | 14.68130 | 0.0044669 | 0.0401342 |
| RGS4 | 2.388592 | 7.191836 | 57.83783 | 0.0000446 | 0.0030414 |
| CIART | 2.392362 | 4.790032 | 92.17636 | 0.0000065 | 0.0014424 |
| CREBRF | 2.394751 | 6.655744 | 61.63792 | 0.0000343 | 0.0028119 |
| HLA-E | 2.405630 | 7.998819 | 48.34451 | 0.0000881 | 0.0042472 |
| TPBG | 2.407003 | 6.893303 | 69.75091 | 0.0000198 | 0.0022405 |
| TG | 2.407486 | 3.313804 | 64.08243 | 0.0000274 | 0.0025570 |
| TNFRSF1B | 2.408509 | 2.494308 | 40.14760 | 0.0004310 | 0.0104419 |
| CXCL6 | 2.410656 | 2.592254 | 46.90449 | 0.0002179 | 0.0073154 |
| TET3 | 2.410728 | 4.493949 | 52.52010 | 0.0000648 | 0.0036353 |
| NR6A1 | 2.414602 | 2.865905 | 52.70812 | 0.0000604 | 0.0034872 |
| MYO3A | 2.414730 | 2.342404 | 33.47029 | 0.0011067 | 0.0174366 |
| PARP9 | 2.414755 | 5.806204 | 16.66523 | 0.0030981 | 0.0322639 |
| BCL6 | 2.422277 | 6.040827 | 70.56460 | 0.0000190 | 0.0021905 |
| INSYN2B | 2.430209 | 2.488640 | 42.73621 | 0.0004134 | 0.0101815 |
| NBPF19 | 2.433163 | 3.774509 | 53.83972 | 0.0000591 | 0.0034529 |
| LOXL2 | 2.435605 | 9.183272 | 31.59394 | 0.0004002 | 0.0100799 |
| HIVEP1 | 2.437602 | 6.216610 | 37.05956 | 0.0002296 | 0.0075043 |
| MAPK13 | 2.450262 | 2.028206 | 22.03778 | 0.0055114 | 0.0462644 |
| NEFM | 2.456494 | 2.322909 | 25.11623 | 0.0010629 | 0.0171617 |
| SOX17 | 2.458071 | 2.337055 | 58.62437 | 0.0009577 | 0.0161040 |
| DUSP4 | 2.462814 | 3.126499 | 58.04295 | 0.0000427 | 0.0030190 |
| SLCO2A1 | 2.466396 | 2.839009 | 37.82173 | 0.0002136 | 0.0072524 |
| CA12 | 2.469995 | 4.680373 | 66.11578 | 0.0000262 | 0.0025480 |
| PDE10A | 2.477695 | 5.789936 | 54.34658 | 0.0000571 | 0.0033950 |
| KLF4 | 2.478537 | 2.201813 | 47.66737 | 0.0019818 | 0.0245703 |
| PTGER4 | 2.483473 | 2.339761 | 35.38493 | 0.0008789 | 0.0152928 |
| IL15RA | 2.483720 | 2.576531 | 27.93078 | 0.0006078 | 0.0124300 |
| KLF5 | 2.485018 | 5.690175 | 73.25404 | 0.0000166 | 0.0019783 |
| BHLHE40 | 2.496503 | 7.578998 | 58.09862 | 0.0000445 | 0.0030414 |
| EDEM1 | 2.498534 | 5.605145 | 25.98581 | 0.0007726 | 0.0142520 |
| MEDAG | 2.503234 | 3.778340 | 64.17896 | 0.0000292 | 0.0026381 |
| TIGD3 | 2.508575 | 2.188260 | 32.33343 | 0.0019804 | 0.0245703 |
| SLC2A3 | 2.509515 | 7.984835 | 31.98997 | 0.0003834 | 0.0098214 |
| FNIP2 | 2.511309 | 7.557486 | 28.91908 | 0.0005407 | 0.0116472 |
| LOXL3 | 2.511423 | 3.727307 | 62.42745 | 0.0000329 | 0.0027841 |
| TRAF1 | 2.514945 | 3.056460 | 53.39919 | 0.0000610 | 0.0035080 |
| KLF10 | 2.515128 | 7.427442 | 50.13561 | 0.0000770 | 0.0039749 |
| UGCG | 2.518274 | 7.585201 | 83.56366 | 0.0000096 | 0.0015449 |
| VEGFC | 2.535167 | 4.635154 | 94.71748 | 0.0000058 | 0.0014052 |
| CPM | 2.545456 | 3.022765 | 67.41990 | 0.0000223 | 0.0023479 |
| PHLDA2 | 2.549979 | 5.303923 | 43.22775 | 0.0001324 | 0.0053487 |
| OVGP1 | 2.567849 | 2.209877 | 35.06004 | 0.0014456 | 0.0205290 |
| SPINT1 | 2.569089 | 2.654571 | 59.90095 | 0.0000670 | 0.0037034 |
| APOL6 | 2.571367 | 3.725652 | 28.88805 | 0.0005427 | 0.0116535 |
| STC2 | 2.574370 | 8.153217 | 47.92961 | 0.0000909 | 0.0043208 |
| CSF1 | 2.579403 | 6.467006 | 103.92047 | 0.0000040 | 0.0012869 |
| ADIRF-AS1 | 2.579661 | 2.075189 | 18.68391 | 0.0030687 | 0.0321160 |
| F2RL1 | 2.589487 | 4.255967 | 53.54420 | 0.0000603 | 0.0034872 |
| CD101 | 2.589927 | 2.004320 | 17.59860 | 0.0043811 | 0.0395997 |
| HERC6 | 2.604753 | 5.322727 | 13.54169 | 0.0055977 | 0.0465044 |
| IL1R1 | 2.605356 | 7.513133 | 24.61197 | 0.0009232 | 0.0157850 |
| TNFSF9 | 2.605547 | 3.160242 | 47.56645 | 0.0000935 | 0.0044085 |
| GRB7 | 2.610120 | 2.239059 | 26.62211 | 0.0010549 | 0.0170510 |
| BMPR1B | 2.619521 | 2.968540 | 62.37361 | 0.0000318 | 0.0027505 |
| TNFRSF10D | 2.620613 | 7.480225 | 14.94479 | 0.0042470 | 0.0389248 |
| HOXA5 | 2.628181 | 3.550076 | 65.55187 | 0.0000275 | 0.0025578 |
| PMAIP1 | 2.637589 | 5.368933 | 70.49822 | 0.0000210 | 0.0022998 |
| TMED7-TICAM2 | 2.639298 | 4.595094 | 49.37553 | 0.0000815 | 0.0040633 |
| PARP14 | 2.642709 | 6.036682 | 14.89076 | 0.0042909 | 0.0391865 |
| H2BC8 | 2.643823 | 2.446299 | 49.98735 | 0.0002391 | 0.0076380 |
| SGK1 | 2.647606 | 8.446304 | 81.45867 | 0.0000106 | 0.0015867 |
| SBNO2 | 2.656249 | 4.523733 | 36.87898 | 0.0002336 | 0.0075257 |
| PDCD1LG2 | 2.657190 | 3.062061 | 37.68423 | 0.0002164 | 0.0072960 |
| ITGA5 | 2.665103 | 9.258279 | 24.97348 | 0.0008803 | 0.0152928 |
| KCNN1 | 2.667134 | 2.217189 | 49.10990 | 0.0010080 | 0.0165225 |
| SELPLG | 2.668810 | 3.424445 | 50.72737 | 0.0000737 | 0.0038614 |
| SP100 | 2.676217 | 6.869313 | 49.92929 | 0.0000782 | 0.0039752 |
| SERPINB2 | 2.677729 | 2.534626 | 32.68863 | 0.0003559 | 0.0094353 |
| GABRR2 | 2.682761 | 2.202704 | 29.53987 | 0.0010748 | 0.0171617 |
| WNK4 | 2.682955 | 3.808848 | 82.80079 | 0.0000099 | 0.0015449 |
| TM4SF1 | 2.691544 | 5.916868 | 102.61484 | 0.0000042 | 0.0012883 |
| BMP6 | 2.691649 | 5.361842 | 39.69598 | 0.0001799 | 0.0065847 |
| CCL2 | 2.692769 | 7.847590 | 52.45024 | 0.0000652 | 0.0036429 |
| CHD2 | 2.697284 | 7.759830 | 61.58868 | 0.0000357 | 0.0028350 |
| ADGRE5 | 2.699674 | 4.148737 | 62.43113 | 0.0000339 | 0.0028119 |
| INHBE | 2.700693 | 3.138498 | 27.32567 | 0.0006539 | 0.0129541 |
| ZBTB21 | 2.703003 | 4.756237 | 52.63773 | 0.0000643 | 0.0036260 |
| CPA4 | 2.708803 | 8.661667 | 57.24498 | 0.0000470 | 0.0031122 |
| H2BC18 | 2.711889 | 1.912383 | 47.22384 | 0.0053097 | 0.0450662 |
| SLC19A2 | 2.718296 | 4.679205 | 69.11184 | 0.0000230 | 0.0023965 |
| PLOD2 | 2.720926 | 9.054149 | 33.04360 | 0.0003428 | 0.0093435 |
| PRR5L | 2.722209 | 2.279041 | 41.67201 | 0.0005820 | 0.0120858 |
| BHLHE41 | 2.722265 | 5.510344 | 79.09856 | 0.0000128 | 0.0017608 |
| PTGES | 2.722689 | 4.499698 | 47.92230 | 0.0000909 | 0.0043208 |
| IP6K3 | 2.727148 | 3.257753 | 58.45228 | 0.0000435 | 0.0030255 |
| JUNB | 2.744661 | 8.839775 | 69.48414 | 0.0000218 | 0.0023298 |
| RBM47 | 2.744715 | 2.345884 | 34.59026 | 0.0003440 | 0.0093542 |
| CCNL1 | 2.752683 | 7.774751 | 110.61420 | 0.0000031 | 0.0012769 |
| ARHGEF28 | 2.759261 | 2.802980 | 47.49817 | 0.0000940 | 0.0044212 |
| GALNT12 | 2.762916 | 4.193289 | 63.99295 | 0.0000309 | 0.0027158 |
| RFLNA | 2.764764 | 4.147928 | 84.39458 | 0.0000095 | 0.0015449 |
| SPHK1 | 2.772888 | 6.222188 | 123.11496 | 0.0000020 | 0.0010944 |
| PER1 | 2.773211 | 6.060084 | 87.44212 | 0.0000083 | 0.0015101 |
| FOSL1 | 2.786567 | 3.793474 | 112.58099 | 0.0000029 | 0.0012769 |
| TMEM200A | 2.789991 | 6.447756 | 89.28898 | 0.0000075 | 0.0015101 |
| KCNG1 | 2.794918 | 5.266295 | 87.31263 | 0.0000083 | 0.0015101 |
| APOL3 | 2.797154 | 2.342614 | 21.18435 | 0.0014922 | 0.0208704 |
| ARRDC3 | 2.797668 | 6.423077 | 42.94122 | 0.0001356 | 0.0054314 |
| CDC14A | 2.798065 | 4.378705 | 46.86708 | 0.0000987 | 0.0045511 |
| SLC5A3 | 2.807390 | 6.175750 | 45.49239 | 0.0001100 | 0.0048017 |
| GPR87 | 2.819893 | 2.113681 | 45.56112 | 0.0012731 | 0.0189112 |
| HAP1 | 2.828557 | 1.875954 | 17.09753 | 0.0050469 | 0.0435322 |
| ATF3 | 2.834749 | 6.181991 | 106.16959 | 0.0000037 | 0.0012869 |
| LOX | 2.837510 | 10.821083 | 42.10166 | 0.0001456 | 0.0056996 |
| ICAM1 | 2.844774 | 5.364546 | 70.47057 | 0.0000214 | 0.0023028 |
| ANXA10 | 2.847749 | 1.829139 | 51.94006 | 0.0062174 | 0.0495546 |
| H2BC6 | 2.848198 | 1.878000 | 30.25758 | 0.0047705 | 0.0419783 |
| SAMD9L | 2.854908 | 3.920715 | 16.87209 | 0.0029874 | 0.0315855 |
| ATP10A | 2.857127 | 4.766572 | 49.82133 | 0.0000788 | 0.0039967 |
| PTGS1 | 2.871569 | 4.109720 | 40.56185 | 0.0001665 | 0.0062233 |
| PPP1R15A | 2.888216 | 8.511152 | 94.88975 | 0.0000058 | 0.0014052 |
| FAM83G | 2.890823 | 4.646828 | 39.07453 | 0.0001903 | 0.0068633 |
| IFIT1 | 2.897333 | 7.041470 | 17.89687 | 0.0025062 | 0.0285093 |
| TMEM158 | 2.907377 | 4.242491 | 89.36416 | 0.0000077 | 0.0015101 |
| IPMK | 2.909372 | 3.921477 | 59.40324 | 0.0000409 | 0.0029867 |
| TMEM119 | 2.916719 | 2.770240 | 42.17314 | 0.0001448 | 0.0056924 |
| FOS | 2.924209 | 8.202713 | 111.89453 | 0.0000030 | 0.0012769 |
| GCH1 | 2.930393 | 3.821751 | 40.90273 | 0.0001616 | 0.0061210 |
| ADCY10 | 2.934266 | 2.007223 | 19.27309 | 0.0020014 | 0.0246730 |
| AGTR1 | 2.936738 | 1.985556 | 31.28869 | 0.0020865 | 0.0253049 |
| ZSWIM4 | 2.947280 | 3.828771 | 35.24651 | 0.0002738 | 0.0083105 |
| SLC20A1 | 2.959516 | 8.545497 | 43.95958 | 0.0001246 | 0.0052069 |
| OSMR | 2.968027 | 6.966265 | 28.35249 | 0.0005780 | 0.0120621 |
| LINC01119 | 2.971468 | 2.172242 | 58.56300 | 0.0005557 | 0.0118139 |
| TNFRSF6B | 2.973553 | 2.364744 | 31.54205 | 0.0004024 | 0.0100851 |
| TLR4 | 2.977475 | 4.828423 | 42.32298 | 0.0001429 | 0.0056540 |
| NPIPB6 | 2.977480 | 3.411860 | 58.29854 | 0.0000439 | 0.0030414 |
| IL6 | 2.982850 | 4.006756 | 88.50850 | 0.0000082 | 0.0015101 |
| TMEM255B | 2.982863 | 3.190498 | 86.45227 | 0.0000084 | 0.0015101 |
| APLN | 2.991301 | 1.846589 | 47.13043 | 0.0042620 | 0.0390111 |
| ADM5 | 2.995367 | 1.815252 | 39.98235 | 0.0050671 | 0.0436486 |
| PFKFB4 | 2.996145 | 4.417500 | 61.31929 | 0.0000363 | 0.0028708 |
| EGR2 | 2.997124 | 4.464698 | 91.86878 | 0.0000071 | 0.0015101 |
| FNDC11 | 3.003023 | 2.063081 | 24.45838 | 0.0010925 | 0.0173168 |
| RELB | 3.007213 | 5.745798 | 101.00085 | 0.0000046 | 0.0012883 |
| TAF4B | 3.014949 | 3.286624 | 92.77776 | 0.0000063 | 0.0014380 |
| SH2B3 | 3.016999 | 5.564816 | 47.23800 | 0.0000959 | 0.0044695 |
| PCDH8 | 3.023577 | 2.109310 | 32.17253 | 0.0007661 | 0.0142109 |
| TFPI2 | 3.045211 | 7.289627 | 76.41806 | 0.0000156 | 0.0019665 |
| SAMHD1 | 3.052257 | 6.155858 | 33.54926 | 0.0003252 | 0.0090658 |
| GFPT2 | 3.053507 | 7.114968 | 55.27068 | 0.0000536 | 0.0032875 |
| IL12A | 3.074159 | 1.954999 | 35.21462 | 0.0018710 | 0.0237584 |
| NFKB2 | 3.074821 | 5.527933 | 111.23830 | 0.0000030 | 0.0012769 |
| MYO10 | 3.075920 | 5.670992 | 51.52942 | 0.0000696 | 0.0037609 |
| SLC25A25 | 3.094355 | 5.643307 | 49.35799 | 0.0000816 | 0.0040633 |
| PAPPA | 3.106189 | 7.907271 | 78.09810 | 0.0000144 | 0.0019055 |
| KCNJ6 | 3.107220 | 3.589969 | 66.83040 | 0.0000262 | 0.0025480 |
| PLA2G4A | 3.110495 | 4.074551 | 82.71147 | 0.0000115 | 0.0016253 |
| IDI2-AS1 | 3.112656 | 1.917110 | 26.86395 | 0.0021878 | 0.0261013 |
| CDC42EP2 | 3.119416 | 4.920009 | 43.94273 | 0.0001248 | 0.0052069 |
| NBPF10 | 3.123370 | 5.585064 | 58.08067 | 0.0000445 | 0.0030414 |
| PARP10 | 3.156709 | 4.824737 | 34.79916 | 0.0002864 | 0.0084898 |
| NFKBIZ | 3.159083 | 7.121925 | 67.68861 | 0.0000249 | 0.0025076 |
| CD83 | 3.173820 | 4.440632 | 100.41670 | 0.0000049 | 0.0013075 |
| PER2 | 3.177066 | 3.949798 | 105.20435 | 0.0000038 | 0.0012869 |
| SUSD3 | 3.177775 | 1.913574 | 49.11554 | 0.0019182 | 0.0240671 |
| NPIPB9 | 3.187425 | 3.056459 | 85.96106 | 0.0000090 | 0.0015377 |
| TNFSF4 | 3.194547 | 4.449263 | 39.82799 | 0.0001777 | 0.0065217 |
| CSRNP1 | 3.209089 | 6.393243 | 77.56168 | 0.0000148 | 0.0019306 |
| LIF | 3.218333 | 3.313136 | 68.51894 | 0.0000238 | 0.0024308 |
| CDCP1 | 3.221546 | 3.220219 | 40.95561 | 0.0001608 | 0.0061107 |
| CFAP43 | 3.236729 | 2.165087 | 49.14447 | 0.0002905 | 0.0085601 |
| IFI6 | 3.245873 | 9.114637 | 16.84248 | 0.0030030 | 0.0316902 |
| CYP1B1 | 3.250809 | 7.104491 | 78.42151 | 0.0000141 | 0.0018880 |
| HELZ2 | 3.260663 | 3.448995 | 29.49406 | 0.0005059 | 0.0113044 |
| IFIH1 | 3.261873 | 4.786974 | 19.15159 | 0.0020406 | 0.0249842 |
| MAP3K8 | 3.271886 | 4.537469 | 125.90809 | 0.0000018 | 0.0010564 |
| DDX58 | 3.283058 | 6.746199 | 25.90700 | 0.0007804 | 0.0143064 |
| MYCT1 | 3.289963 | 2.046555 | 40.95518 | 0.0006164 | 0.0125473 |
| CDH16 | 3.290525 | 1.742021 | 60.36658 | 0.0044961 | 0.0403046 |
| SIX4 | 3.320190 | 3.895493 | 92.89530 | 0.0000071 | 0.0015101 |
| NR1D1 | 3.343418 | 4.357002 | 106.64788 | 0.0000039 | 0.0012869 |
| IFITM1 | 3.349915 | 8.961878 | 31.36005 | 0.0004105 | 0.0101815 |
| MAFF | 3.370586 | 5.316654 | 148.11264 | 0.0000009 | 0.0008348 |
| TRIM14 | 3.388914 | 4.091813 | 23.23787 | 0.0011119 | 0.0174687 |
| PTPRN | 3.400174 | 5.267114 | 87.46905 | 0.0000092 | 0.0015377 |
| PLAUR | 3.405416 | 6.861024 | 104.07963 | 0.0000047 | 0.0012892 |
| ANKS4B | 3.408031 | 2.135298 | 51.93580 | 0.0002362 | 0.0075737 |
| NFKBIA | 3.417202 | 8.391397 | 107.47928 | 0.0000038 | 0.0012869 |
| BST2 | 3.420476 | 7.307547 | 28.62527 | 0.0005597 | 0.0118432 |
| CDK5R1 | 3.428745 | 4.033448 | 61.98541 | 0.0000348 | 0.0028119 |
| MLKL | 3.442330 | 2.640487 | 32.79267 | 0.0003520 | 0.0094101 |
| GIPC3 | 3.444105 | 2.761143 | 35.57037 | 0.0002652 | 0.0081698 |
| NPC1L1 | 3.472580 | 1.880101 | 42.48278 | 0.0013512 | 0.0196696 |
| MYRFL | 3.473980 | 3.090140 | 112.05350 | 0.0000029 | 0.0012769 |
| CXCR1 | 3.476321 | 1.651404 | 65.32856 | 0.0057019 | 0.0469329 |
| PCDH15 | 3.477425 | 2.628085 | 60.98567 | 0.0000370 | 0.0028841 |
| SNAI1 | 3.501171 | 3.290060 | 116.77807 | 0.0000025 | 0.0012520 |
| ANKRD33B | 3.521136 | 3.588617 | 84.47745 | 0.0000106 | 0.0015867 |
| USP18 | 3.526600 | 5.093084 | 22.54242 | 0.0012256 | 0.0185422 |
| PTX3 | 3.554543 | 8.390962 | 123.98638 | 0.0000020 | 0.0010944 |
| NFATC2 | 3.555795 | 3.933467 | 108.29201 | 0.0000037 | 0.0012869 |
| SERPINE1 | 3.556188 | 10.606702 | 103.55315 | 0.0000043 | 0.0012883 |
| SLC2A5 | 3.566019 | 3.689098 | 139.12562 | 0.0000012 | 0.0008663 |
| MICB | 3.587570 | 4.564095 | 128.86532 | 0.0000017 | 0.0010207 |
| ZBTB2 | 3.600436 | 6.397979 | 128.33353 | 0.0000018 | 0.0010564 |
| LINC01823 | 3.619946 | 1.710207 | 70.23833 | 0.0032122 | 0.0329840 |
| SLC12A8 | 3.620080 | 6.029256 | 138.55951 | 0.0000012 | 0.0008663 |
| SAMD9 | 3.629801 | 5.398846 | 25.32834 | 0.0008405 | 0.0149144 |
| IRF8 | 3.652257 | 3.459020 | 129.81346 | 0.0000016 | 0.0010207 |
| STC1 | 3.653529 | 4.152861 | 114.32324 | 0.0000030 | 0.0012769 |
| APCDD1L | 3.695406 | 2.896546 | 63.34529 | 0.0000321 | 0.0027505 |
| IFI27 | 3.706511 | 5.887802 | 13.31120 | 0.0058680 | 0.0476806 |
| GAL3ST1 | 3.711185 | 2.265829 | 88.74739 | 0.0000349 | 0.0028119 |
| SRGN | 3.730504 | 3.888739 | 90.97631 | 0.0000079 | 0.0015101 |
| BIRC3 | 3.746385 | 3.629215 | 142.35202 | 0.0000011 | 0.0008348 |
| NR4A3 | 3.746540 | 4.579866 | 99.92274 | 0.0000055 | 0.0014052 |
| SAA1 | 3.753236 | 2.059358 | 53.31650 | 0.0001962 | 0.0069235 |
| NXPE2 | 3.755393 | 2.052772 | 74.76876 | 0.0002086 | 0.0071561 |
| CXCL8 | 3.764355 | 3.864053 | 93.14546 | 0.0000072 | 0.0015101 |
| ACTBL2 | 3.808624 | 3.464013 | 75.19980 | 0.0000166 | 0.0019783 |
| FOSB | 3.811074 | 3.547716 | 90.06315 | 0.0000082 | 0.0015101 |
| TNC | 3.811429 | 8.709608 | 29.60629 | 0.0004994 | 0.0112467 |
| SPOCD1 | 3.815799 | 3.920872 | 142.58956 | 0.0000011 | 0.0008348 |
| CXCL3 | 3.824323 | 3.424551 | 90.05022 | 0.0000083 | 0.0015101 |
| HAS1 | 3.840127 | 2.411141 | 95.33842 | 0.0000057 | 0.0014052 |
| NR4A1AS | 3.850720 | 2.651442 | 58.71612 | 0.0000427 | 0.0030190 |
| ZC3H12A | 3.904393 | 5.451827 | 178.02256 | 0.0000004 | 0.0007127 |
| SENP3-EIF4A1 | 3.910008 | 2.840661 | 45.47944 | 0.0001101 | 0.0048017 |
| SUCNR1 | 3.918909 | 6.828456 | 151.63876 | 0.0000009 | 0.0008217 |
| HLF | 3.969301 | 2.010502 | 61.39614 | 0.0001951 | 0.0069235 |
| BAAT | 3.986116 | 1.875604 | 82.83832 | 0.0005595 | 0.0118432 |
| ISG15 | 3.987277 | 8.765821 | 28.31308 | 0.0005807 | 0.0120834 |
| HSPA6 | 4.021950 | 5.075571 | 57.94640 | 0.0000449 | 0.0030492 |
| ISG20 | 4.034635 | 3.041143 | 30.04930 | 0.0004749 | 0.0110002 |
| IFIT2 | 4.073136 | 5.933346 | 24.85427 | 0.0008941 | 0.0154317 |
| IFI44 | 4.086988 | 4.919038 | 28.00651 | 0.0006023 | 0.0123602 |
| NR4A1 | 4.159769 | 6.218755 | 192.68473 | 0.0000003 | 0.0007000 |
| CD68 | 4.171354 | 3.317853 | 34.80694 | 0.0002861 | 0.0084898 |
| DHX58 | 4.190837 | 2.712811 | 16.60052 | 0.0031338 | 0.0324848 |
| HIVEP2 | 4.198906 | 6.659401 | 48.31647 | 0.0000882 | 0.0042472 |
| NT5E | 4.316077 | 7.310700 | 108.33623 | 0.0000040 | 0.0012869 |
| C7orf61 | 4.365896 | 2.734189 | 77.09207 | 0.0000151 | 0.0019319 |
| NR4A2 | 4.367729 | 3.981776 | 191.45573 | 0.0000003 | 0.0007000 |
| FERMT3 | 4.484359 | 2.883749 | 103.27124 | 0.0000046 | 0.0012883 |
| IRF7 | 4.489884 | 5.679134 | 62.13961 | 0.0000345 | 0.0028119 |
| TGIF2-RAB5IF | 4.494917 | 4.362682 | 190.74201 | 0.0000003 | 0.0007000 |
| GDF15 | 4.512745 | 6.839520 | 173.03468 | 0.0000005 | 0.0007127 |
| CD200R1 | 4.523281 | 2.018138 | 70.30699 | 0.0000674 | 0.0037157 |
| GREM1 | 4.546835 | 6.032808 | 90.62883 | 0.0000080 | 0.0015101 |
| NUAK2 | 4.662422 | 5.571280 | 189.51363 | 0.0000003 | 0.0007000 |
| PTAFR | 4.698314 | 2.295618 | 58.87163 | 0.0000423 | 0.0030190 |
| HAS2 | 4.774514 | 5.249723 | 98.86211 | 0.0000057 | 0.0014052 |
| GALNT15 | 4.843532 | 3.923216 | 119.59236 | 0.0000027 | 0.0012769 |
| SPDYA | 4.964848 | 3.560782 | 187.05871 | 0.0000004 | 0.0007000 |
| CXCL1 | 4.990861 | 2.433813 | 130.67746 | 0.0000016 | 0.0010207 |
| OSM | 5.000936 | 2.248774 | 46.25914 | 0.0001035 | 0.0046794 |
| TNFAIP3 | 5.158030 | 8.324103 | 97.05961 | 0.0000061 | 0.0014197 |
| MRC1 | 5.160553 | 3.048629 | 175.47488 | 0.0000005 | 0.0007127 |
| MX2 | 5.179423 | 4.265989 | 16.50202 | 0.0031890 | 0.0328799 |
| CCL7 | 5.291829 | 4.389444 | 162.54788 | 0.0000007 | 0.0007268 |
| IL1B | 5.353070 | 2.593641 | 121.05582 | 0.0000021 | 0.0011397 |
| IFIT3 | 5.363579 | 6.476869 | 32.11417 | 0.0003783 | 0.0097807 |
| RSAD2 | 5.381729 | 4.795030 | 15.69902 | 0.0036876 | 0.0358349 |
| CXCL2 | 5.393316 | 4.112167 | 241.10541 | 0.0000001 | 0.0007000 |
| CA9 | 5.446761 | 3.354625 | 105.39236 | 0.0000044 | 0.0012883 |
| IFNB1 | 5.579821 | 2.416278 | 14.13598 | 0.0049686 | 0.0431032 |
| CMPK2 | 5.739321 | 4.968540 | 18.36468 | 0.0023186 | 0.0270494 |
| IFI44L | 5.886140 | 5.480482 | 29.97991 | 0.0004786 | 0.0110238 |
| OAS3 | 6.040390 | 5.476378 | 55.45416 | 0.0000530 | 0.0032675 |
| ANGPTL4 | 6.667607 | 7.693979 | 263.86127 | 0.0000001 | 0.0007000 |
| MX1 | 6.839104 | 8.213029 | 71.14538 | 0.0000206 | 0.0022828 |
| OAS1 | 6.914038 | 6.380700 | 55.83812 | 0.0000516 | 0.0032300 |
| OAS2 | 7.149848 | 5.743360 | 38.37334 | 0.0002029 | 0.0070229 |
| PTGS2 | 7.172085 | 7.222030 | 227.27911 | 0.0000002 | 0.0007000 |
| IL11 | 7.811430 | 5.185583 | 285.28029 | 0.0000001 | 0.0007000 |
[2]
Conduct non-thresholded gene set enrichment analysis using the ranked set of genes from Assignment #2.
I used GSEA4.2.3 in this part; Cytoscape 3.9.1, its Enrichment Map application and AutoAnnotation (1.3.5) application for the downstream analysis. [4]
knitr::kable(ranked_gene_list_na_pos_versus_na_neg_1648855165869, caption = 'Table 2. Ranked Gene List Virus vs. Mock')
| NAME | SCORE |
|---|---|
| IL11 | 7.811430 |
| PTGS2 | 7.172085 |
| OAS2 | 7.149848 |
| OAS1 | 6.914038 |
| MX1 | 6.839104 |
| ANGPTL4 | 6.667607 |
| OAS3 | 6.040390 |
| IFI44L | 5.886140 |
| CMPK2 | 5.739321 |
| IFNB1 | 5.579821 |
| CA9 | 5.446761 |
| CXCL2 | 5.393316 |
| RSAD2 | 5.381730 |
| IFIT3 | 5.363579 |
| IL1B | 5.353070 |
| CCL7 | 5.291829 |
| MX2 | 5.179423 |
| MRC1 | 5.160553 |
| TNFAIP3 | 5.158030 |
| OSM | 5.000936 |
| CXCL1 | 4.990861 |
| SPDYA | 4.964848 |
| GALNT15 | 4.843532 |
| HAS2 | 4.774514 |
| PTAFR | 4.698314 |
| NUAK2 | 4.662423 |
| GREM1 | 4.546835 |
| CD200R1 | 4.523281 |
| GDF15 | 4.512745 |
| TGIF2-RAB5IF | 4.494917 |
| IRF7 | 4.489884 |
| FERMT3 | 4.484359 |
| NR4A2 | 4.367728 |
| C7orf61 | 4.365896 |
| NT5E | 4.316078 |
| HIVEP2 | 4.198906 |
| DHX58 | 4.190837 |
| CD68 | 4.171354 |
| NR4A1 | 4.159769 |
| IFI44 | 4.086988 |
| IFIT2 | 4.073136 |
| ISG20 | 4.034635 |
| HSPA6 | 4.021950 |
| ISG15 | 3.987277 |
| BAAT | 3.986116 |
| HLF | 3.969301 |
| SUCNR1 | 3.918909 |
| SENP3-EIF4A1 | 3.910008 |
| ZC3H12A | 3.904393 |
| NR4A1AS | 3.850720 |
| HAS1 | 3.840127 |
| CXCL3 | 3.824323 |
| SPOCD1 | 3.815799 |
| TNC | 3.811428 |
| FOSB | 3.811074 |
| ACTBL2 | 3.808624 |
| CXCL8 | 3.764355 |
| NXPE2 | 3.755393 |
| SAA1 | 3.753236 |
| NR4A3 | 3.746540 |
| BIRC3 | 3.746385 |
| SRGN | 3.730504 |
| GAL3ST1 | 3.711185 |
| IFI27 | 3.706511 |
| APCDD1L | 3.695406 |
| STC1 | 3.653529 |
| IRF8 | 3.652257 |
| SAMD9 | 3.629801 |
| SLC12A8 | 3.620080 |
| LINC01823 | 3.619946 |
| ZBTB2 | 3.600436 |
| MICB | 3.587570 |
| SLC2A5 | 3.566019 |
| SERPINE1 | 3.556188 |
| NFATC2 | 3.555795 |
| PTX3 | 3.554543 |
| USP18 | 3.526600 |
| ANKRD33B | 3.521136 |
| SNAI1 | 3.501171 |
| PCDH15 | 3.477425 |
| CXCR1 | 3.476321 |
| MYRFL | 3.473980 |
| NPC1L1 | 3.472580 |
| GIPC3 | 3.444105 |
| MLKL | 3.442330 |
| CDK5R1 | 3.428745 |
| BST2 | 3.420476 |
| NFKBIA | 3.417202 |
| ANKS4B | 3.408031 |
| PLAUR | 3.405416 |
| PTPRN | 3.400174 |
| TRIM14 | 3.388913 |
| MAFF | 3.370586 |
| IFITM1 | 3.349915 |
| NR1D1 | 3.343418 |
| SIX4 | 3.320190 |
| CDH16 | 3.290525 |
| MYCT1 | 3.289963 |
| DDX58 | 3.283058 |
| MAP3K8 | 3.271886 |
| IFIH1 | 3.261873 |
| HELZ2 | 3.260663 |
| CYP1B1 | 3.250809 |
| IFI6 | 3.245873 |
| CFAP43 | 3.236729 |
| CDCP1 | 3.221546 |
| LIF | 3.218332 |
| CSRNP1 | 3.209090 |
| TNFSF4 | 3.194547 |
| NPIPB9 | 3.187425 |
| SUSD3 | 3.177775 |
| PER2 | 3.177066 |
| CD83 | 3.173820 |
| NFKBIZ | 3.159083 |
| PARP10 | 3.156709 |
| NBPF10 | 3.123370 |
| CDC42EP2 | 3.119416 |
| IDI2-AS1 | 3.112656 |
| PLA2G4A | 3.110495 |
| KCNJ6 | 3.107220 |
| PAPPA | 3.106189 |
| SLC25A25 | 3.094355 |
| MYO10 | 3.075920 |
| NFKB2 | 3.074822 |
| IL12A | 3.074159 |
| GFPT2 | 3.053507 |
| SAMHD1 | 3.052257 |
| TFPI2 | 3.045211 |
| PCDH8 | 3.023577 |
| SH2B3 | 3.016999 |
| TAF4B | 3.014949 |
| RELB | 3.007213 |
| FNDC11 | 3.003023 |
| EGR2 | 2.997124 |
| PFKFB4 | 2.996145 |
| ADM5 | 2.995367 |
| APLN | 2.991301 |
| TMEM255B | 2.982863 |
| IL6 | 2.982850 |
| NPIPB6 | 2.977480 |
| TLR4 | 2.977475 |
| TNFRSF6B | 2.973553 |
| LINC01119 | 2.971468 |
| OSMR | 2.968027 |
| SLC20A1 | 2.959516 |
| ZSWIM4 | 2.947280 |
| AGTR1 | 2.936738 |
| ADCY10 | 2.934266 |
| GCH1 | 2.930393 |
| FOS | 2.924209 |
| TMEM119 | 2.916719 |
| IPMK | 2.909372 |
| TMEM158 | 2.907376 |
| IFIT1 | 2.897333 |
| FAM83G | 2.890823 |
| PPP1R15A | 2.888216 |
| PTGS1 | 2.871569 |
| ATP10A | 2.857127 |
| SAMD9L | 2.854908 |
| H2BC6 | 2.848198 |
| ANXA10 | 2.847749 |
| ICAM1 | 2.844774 |
| LOX | 2.837510 |
| ATF3 | 2.834750 |
| HAP1 | 2.828557 |
| GPR87 | 2.819893 |
| SLC5A3 | 2.807390 |
| CDC14A | 2.798065 |
| ARRDC3 | 2.797668 |
| APOL3 | 2.797154 |
| KCNG1 | 2.794918 |
| TMEM200A | 2.789991 |
| FOSL1 | 2.786567 |
| PER1 | 2.773211 |
| SPHK1 | 2.772888 |
| RFLNA | 2.764764 |
| GALNT12 | 2.762916 |
| ARHGEF28 | 2.759261 |
| CCNL1 | 2.752683 |
| RBM47 | 2.744715 |
| JUNB | 2.744661 |
| IP6K3 | 2.727148 |
| PTGES | 2.722689 |
| BHLHE41 | 2.722265 |
| PRR5L | 2.722209 |
| PLOD2 | 2.720926 |
| SLC19A2 | 2.718296 |
| H2BC18 | 2.711889 |
| CPA4 | 2.708803 |
| ZBTB21 | 2.703003 |
| INHBE | 2.700693 |
| ADGRE5 | 2.699674 |
| CHD2 | 2.697284 |
| CCL2 | 2.692769 |
| BMP6 | 2.691649 |
| TM4SF1 | 2.691544 |
| WNK4 | 2.682955 |
| GABRR2 | 2.682761 |
| SERPINB2 | 2.677729 |
| SP100 | 2.676217 |
| SELPLG | 2.668810 |
| KCNN1 | 2.667134 |
| ITGA5 | 2.665103 |
| PDCD1LG2 | 2.657190 |
| SBNO2 | 2.656249 |
| SGK1 | 2.647606 |
| H2BC8 | 2.643823 |
| PARP14 | 2.642709 |
| TMED7-TICAM2 | 2.639298 |
| PMAIP1 | 2.637589 |
| HOXA5 | 2.628181 |
| TNFRSF10D | 2.620613 |
| BMPR1B | 2.619521 |
| GRB7 | 2.610120 |
| TNFSF9 | 2.605547 |
| IL1R1 | 2.605356 |
| HERC6 | 2.604753 |
| CD101 | 2.589927 |
| F2RL1 | 2.589487 |
| ADIRF-AS1 | 2.579662 |
| CSF1 | 2.579402 |
| STC2 | 2.574370 |
| APOL6 | 2.571367 |
| SPINT1 | 2.569089 |
| OVGP1 | 2.567849 |
| PHLDA2 | 2.549979 |
| CPM | 2.545456 |
| VEGFC | 2.535167 |
| UGCG | 2.518274 |
| KLF10 | 2.515128 |
| TRAF1 | 2.514945 |
| LOXL3 | 2.511423 |
| FNIP2 | 2.511309 |
| SLC2A3 | 2.509515 |
| TIGD3 | 2.508575 |
| MEDAG | 2.503234 |
| EDEM1 | 2.498534 |
| BHLHE40 | 2.496503 |
| KLF5 | 2.485018 |
| IL15RA | 2.483720 |
| PTGER4 | 2.483473 |
| KLF4 | 2.478537 |
| PDE10A | 2.477695 |
| CA12 | 2.469995 |
| SLCO2A1 | 2.466396 |
| DUSP4 | 2.462814 |
| SOX17 | 2.458071 |
| NEFM | 2.456494 |
| MAPK13 | 2.450262 |
| HIVEP1 | 2.437602 |
| LOXL2 | 2.435605 |
| NBPF19 | 2.433163 |
| INSYN2B | 2.430209 |
| BCL6 | 2.422277 |
| PARP9 | 2.414755 |
| MYO3A | 2.414730 |
| NR6A1 | 2.414602 |
| TET3 | 2.410728 |
| CXCL6 | 2.410656 |
| TNFRSF1B | 2.408509 |
| TG | 2.407485 |
| TPBG | 2.407003 |
| HLA-E | 2.405630 |
| CREBRF | 2.394751 |
| CIART | 2.392362 |
| RGS4 | 2.388592 |
| FRMD6 | 2.387872 |
| MALL | 2.383326 |
| INHBA | 2.383219 |
| IRF1 | 2.379943 |
| APOL1 | 2.379876 |
| ADAM32 | 2.376574 |
| AMIGO2 | 2.368723 |
| LSMEM1 | 2.361432 |
| MCTP2 | 2.360615 |
| JUN | 2.358727 |
| ULBP2 | 2.358103 |
| BCAR3 | 2.356021 |
| BCL3 | 2.352478 |
| ELF3 | 2.340596 |
| CD44 | 2.340378 |
| INTS6 | 2.335218 |
| TRIM38 | 2.333957 |
| IRAK2 | 2.332145 |
| SLC22A3 | 2.328724 |
| SLC43A3 | 2.324096 |
| EPHA2 | 2.323694 |
| PDK4 | 2.321624 |
| TAP1 | 2.318335 |
| SLC2A9 | 2.313958 |
| SULF1 | 2.309025 |
| HTR7 | 2.306583 |
| ALDH1A3 | 2.304578 |
| CFB | 2.294208 |
| TRIM25 | 2.294127 |
| DUSP1 | 2.292234 |
| SERPINB8 | 2.291079 |
| BRPF1 | 2.289519 |
| GPR176 | 2.287500 |
| DDIT3 | 2.282792 |
| ITGA4 | 2.280581 |
| RBM15 | 2.273480 |
| HES1 | 2.272304 |
| STEAP1 | 2.269506 |
| SPRED1 | 2.268266 |
| SLC7A5 | 2.268056 |
| ARSI | 2.258777 |
| RASGRF2 | 2.257768 |
| DRAM1 | 2.255817 |
| ETV4 | 2.255293 |
| DUSP6 | 2.247526 |
| TNFAIP2 | 2.246920 |
| DTX3L | 2.238600 |
| SMOX | 2.238389 |
| FOXN2 | 2.235189 |
| SPRED3 | 2.232555 |
| MFAP3L | 2.230693 |
| CLK4 | 2.230614 |
| SNAPC1 | 2.224079 |
| GPBP1 | 2.221672 |
| WAKMAR2 | 2.221539 |
| CACTIN | 2.216597 |
| SMURF1 | 2.206765 |
| ATP8B1 | 2.201638 |
| IL1RL1 | 2.200511 |
| TBC1D2 | 2.199856 |
| NEDD9 | 2.198391 |
| ACHE | 2.184266 |
| PTGIS | 2.183773 |
| LRRC8E | 2.181391 |
| SEL1L3 | 2.178554 |
| KCNAB1 | 2.174609 |
| HFE | 2.173138 |
| SEC24A | 2.171192 |
| NFKBID | 2.170539 |
| GADD45B | 2.169566 |
| CHD1 | 2.167425 |
| ZBTB10 | 2.166943 |
| HS6ST2 | 2.158807 |
| EIF2AK2 | 2.155542 |
| LDB2 | 2.155333 |
| STARD13 | 2.146103 |
| GBP3 | 2.142594 |
| TYMP | 2.142315 |
| THY1 | 2.139841 |
| NBPF26 | 2.135125 |
| RXFP1 | 2.133374 |
| TENT5C | 2.132303 |
| IL33 | 2.129479 |
| THSD1 | 2.128001 |
| ARHGAP20 | 2.123484 |
| SLC38A5 | 2.122949 |
| NRG3 | 2.120995 |
| KLF11 | 2.114600 |
| ERRFI1 | 2.113944 |
| MVP | 2.111094 |
| C1QTNF1 | 2.109298 |
| DPP4 | 2.104114 |
| TMEM87B | 2.099924 |
| PDE7A | 2.096324 |
| IFRD1 | 2.095692 |
| ZNF317 | 2.095386 |
| UBASH3B | 2.093595 |
| NBPF14 | 2.093447 |
| HOXA-AS2 | 2.088457 |
| CDH6 | 2.086026 |
| SH3RF1 | 2.084813 |
| FGF7 | 2.083364 |
| SQSTM1 | 2.082316 |
| KLF9 | 2.079559 |
| ADCY7 | 2.076348 |
| RGS16 | 2.075771 |
| CLCF1 | 2.075358 |
| NPIPB15 | 2.073422 |
| RAPGEF2 | 2.072268 |
| PCSK9 | 2.069441 |
| SKIL | 2.067251 |
| DOK5 | 2.067119 |
| ITGA2 | 2.062052 |
| ZNF844 | 2.061578 |
| PDZD2 | 2.058617 |
| TRIM22 | 2.055730 |
| PFKFB3 | 2.054620 |
| BAIAP2L1 | 2.054319 |
| ADM2 | 2.052314 |
| DBP | 2.048629 |
| PIK3CD | 2.048266 |
| HAPLN3 | 2.047483 |
| EMP1 | 2.044095 |
| LIPG | 2.043150 |
| H2BC5 | 2.042077 |
| EVC2 | 2.040074 |
| HRH1 | 2.039099 |
| EGR1 | 2.037634 |
| TLE1 | 2.036129 |
| KCNE4 | 2.032976 |
| CASP4 | 2.031420 |
| ARRDC2 | 2.028687 |
| PIGA | 2.025300 |
| RSRC2 | 2.024864 |
| PIM3 | 2.022238 |
| GTF2IRD1 | 2.022119 |
| LRIG3 | 2.022030 |
| MYD88 | 2.019954 |
| ERO1A | 2.009337 |
| RLF | 2.009219 |
| TGFBI | 2.008175 |
| PTBP3 | 2.004432 |
| ACOT13 | -2.000114 |
| PLK1 | -2.000453 |
| CPVL | -2.005104 |
| FANCL | -2.006840 |
| CHURC1-FNTB | -2.009534 |
| UQCR10 | -2.010785 |
| HADH | -2.010848 |
| SVIP | -2.011910 |
| PPP1R3C | -2.018053 |
| IL17B | -2.019427 |
| CHCHD5 | -2.019536 |
| ATP5MPL | -2.020557 |
| TIMM8B | -2.021806 |
| MYL3 | -2.022303 |
| ATP5MC1 | -2.023177 |
| GSTM4 | -2.024015 |
| DHRS11 | -2.024969 |
| GJA5 | -2.025338 |
| SKA3 | -2.028284 |
| ETFRF1 | -2.029499 |
| PIFO | -2.030697 |
| DNAJC15 | -2.036522 |
| RDH5 | -2.037272 |
| SMDT1 | -2.037491 |
| PET100 | -2.043188 |
| HACD1 | -2.043966 |
| ERH | -2.046144 |
| NIFK-AS1 | -2.046841 |
| PPP1R14C | -2.047443 |
| ATP5MF | -2.049363 |
| NEXN | -2.052929 |
| INKA2-AS1 | -2.054012 |
| NSMCE4A | -2.054613 |
| ST7-AS1 | -2.056492 |
| MMP15 | -2.056655 |
| ABHD11 | -2.056984 |
| PLCXD3 | -2.058581 |
| FAM20A | -2.059499 |
| MYLK | -2.060309 |
| COX8A | -2.061003 |
| ACYP1 | -2.061078 |
| NDUFC1 | -2.062849 |
| DGCR6 | -2.064497 |
| SH3RF2 | -2.067586 |
| TMEM144 | -2.068687 |
| PARP1 | -2.069997 |
| ATP5PD | -2.070352 |
| ICA1 | -2.073635 |
| HIGD2A | -2.075338 |
| CDCA7 | -2.075812 |
| FAM229B | -2.080910 |
| PLPP7 | -2.082147 |
| PHACTR1 | -2.086106 |
| DOK7 | -2.086878 |
| GNG7 | -2.087833 |
| EMP2 | -2.088005 |
| ASB2 | -2.088868 |
| GTSE1 | -2.089318 |
| EFCAB7 | -2.091420 |
| KLHL3 | -2.095120 |
| CDKN2C | -2.096007 |
| MYBPC3 | -2.098119 |
| GUCY1A1 | -2.098464 |
| ATP5MC3 | -2.098677 |
| IL20RA | -2.099056 |
| NAP1L3 | -2.099201 |
| MRPL53 | -2.101326 |
| ANAPC16 | -2.104280 |
| MGST3 | -2.109753 |
| BEX2 | -2.111248 |
| ITM2A | -2.118308 |
| CMC4 | -2.118674 |
| NDUFB2 | -2.118844 |
| UQCRQ | -2.122164 |
| SYNM | -2.122636 |
| ATP5ME | -2.123243 |
| SHCBP1 | -2.129380 |
| HMGN5 | -2.130325 |
| GLIDR | -2.130896 |
| DECR1 | -2.132020 |
| PRC1 | -2.133292 |
| SLC5A1 | -2.133719 |
| TMEM97 | -2.134051 |
| DES | -2.134094 |
| DLGAP1-AS1 | -2.134387 |
| ULK4 | -2.138354 |
| LINC02762 | -2.143704 |
| LINC01351 | -2.148929 |
| MTURN | -2.152774 |
| PMEL | -2.153426 |
| MDP1 | -2.154549 |
| ADCY5 | -2.158902 |
| NDUFS6 | -2.162245 |
| USH1C | -2.162887 |
| INKA2 | -2.162963 |
| DNAJC28 | -2.164137 |
| TAFA2 | -2.164442 |
| MPC1 | -2.165892 |
| PCBD1 | -2.167003 |
| HAND2-AS1 | -2.167011 |
| PLN | -2.167092 |
| ROGDI | -2.167942 |
| MYL9 | -2.170793 |
| HMGN2 | -2.174406 |
| C10orf71 | -2.176344 |
| LINC00880 | -2.177140 |
| HMGCLL1 | -2.178475 |
| RBMS3-AS3 | -2.180075 |
| DAND5 | -2.181967 |
| SSPN | -2.183134 |
| REXO5 | -2.195596 |
| COX6C | -2.195835 |
| LINC00526 | -2.197931 |
| SELENOW | -2.198793 |
| ACADSB | -2.198825 |
| CDC20 | -2.200800 |
| VSNL1 | -2.201836 |
| ACAT1 | -2.204879 |
| GON7 | -2.209077 |
| KCNQ2 | -2.214763 |
| CDC6 | -2.216078 |
| SYNJ2BP-COX16 | -2.221443 |
| PLK4 | -2.221475 |
| SLC2A8 | -2.222631 |
| SCHIP1 | -2.222649 |
| TBX20 | -2.225745 |
| LYPD6 | -2.228899 |
| YPEL1 | -2.232118 |
| KIF22 | -2.232446 |
| ANKRD1 | -2.238789 |
| CTF1 | -2.240603 |
| UNC45B | -2.241744 |
| BCL2A1 | -2.242443 |
| SRP14-AS1 | -2.245190 |
| LYRM9 | -2.250067 |
| NIPSNAP3B | -2.253375 |
| BANCR | -2.253846 |
| DERL3 | -2.255450 |
| HAND2 | -2.255680 |
| ACOT1 | -2.259996 |
| TECRL | -2.264283 |
| CAMK2A | -2.271184 |
| CRIP2 | -2.272728 |
| COX7B | -2.281664 |
| KIAA0319 | -2.281730 |
| HAND1 | -2.281999 |
| S100A6 | -2.287949 |
| CORO6 | -2.289831 |
| BIK | -2.292042 |
| CCND2-AS1 | -2.295584 |
| BOLA1 | -2.296717 |
| NDUFA3 | -2.302154 |
| ACSM5 | -2.303018 |
| DRD1 | -2.305130 |
| COL21A1 | -2.309664 |
| ATP5PF | -2.312218 |
| GP1BB | -2.314509 |
| MORN2 | -2.319151 |
| TK1 | -2.320188 |
| CDCA5 | -2.322462 |
| LRRC52-AS1 | -2.324422 |
| LINC01778 | -2.327603 |
| FPGT | -2.329109 |
| TMOD1 | -2.329743 |
| CLIC5 | -2.332800 |
| PDE6B | -2.333192 |
| C17orf97 | -2.335326 |
| FOXM1 | -2.340321 |
| TRDN-AS1 | -2.340616 |
| CRYAB | -2.344243 |
| HSD17B8 | -2.345639 |
| DNAAF3 | -2.348180 |
| UBE2C | -2.349332 |
| TAGLN3 | -2.354777 |
| ZSCAN16-AS1 | -2.356235 |
| MRPS28 | -2.358498 |
| FN3K | -2.364778 |
| RPA3 | -2.365246 |
| NTF4 | -2.377098 |
| VIPR1 | -2.382483 |
| EPHX2 | -2.384289 |
| HSPB1 | -2.385072 |
| C14orf180 | -2.386624 |
| RCSD1 | -2.389719 |
| C11orf74 | -2.390511 |
| SLC30A3 | -2.395008 |
| PHYHD1 | -2.395036 |
| CENPH | -2.395726 |
| SLC8A1 | -2.406968 |
| TRAPPC6A | -2.409063 |
| NES | -2.412128 |
| NEBL | -2.413640 |
| TMEM141 | -2.417552 |
| LRRC10 | -2.418899 |
| NUSAP1 | -2.423946 |
| GSG1 | -2.424480 |
| KCNS2 | -2.425896 |
| PHOSPHO2 | -2.427787 |
| EXOC3-AS1 | -2.430176 |
| LINC02384 | -2.433270 |
| IDNK | -2.433926 |
| LRRCC1 | -2.437214 |
| SFRP2 | -2.438680 |
| CLYBL | -2.443257 |
| DUSP27 | -2.443680 |
| TSTD1 | -2.443933 |
| HJURP | -2.451450 |
| MTERF2 | -2.454024 |
| ACOT2 | -2.463990 |
| PRADC1 | -2.464355 |
| PHACTR3 | -2.466546 |
| RPE65 | -2.467311 |
| ADHFE1 | -2.470553 |
| ZNF793-AS1 | -2.482754 |
| APOBEC2 | -2.495307 |
| CCNB2 | -2.500282 |
| GIHCG | -2.502606 |
| SMIM5 | -2.507403 |
| UPK1B | -2.518697 |
| C11orf1 | -2.523570 |
| CDK1 | -2.528634 |
| MINCR | -2.531948 |
| PNMT | -2.532905 |
| CKAP2L | -2.533517 |
| DEPDC1 | -2.538446 |
| COX7C | -2.538748 |
| FERMT1 | -2.540029 |
| RMI2 | -2.542336 |
| TYMSOS | -2.551361 |
| NEK2 | -2.561090 |
| SLC26A9 | -2.565358 |
| CRABP2 | -2.565913 |
| MIR1-1HG-AS1 | -2.567849 |
| PKIA | -2.570428 |
| ALDOC | -2.573856 |
| PKMYT1 | -2.575518 |
| GPR183 | -2.580100 |
| SFRP5 | -2.580538 |
| RRM2 | -2.581340 |
| BRINP2 | -2.587693 |
| TMEM163 | -2.592041 |
| BIRC5 | -2.603424 |
| CASQ1 | -2.614019 |
| NDUFB1 | -2.617046 |
| C11orf71 | -2.622072 |
| TMEM71 | -2.625232 |
| MLIP | -2.626909 |
| TYRP1 | -2.631008 |
| UBE2E1 | -2.633303 |
| PDE1A | -2.636327 |
| SLC27A6 | -2.640879 |
| DTL | -2.641167 |
| SGCA | -2.644098 |
| GPX3 | -2.652738 |
| MYZAP | -2.654654 |
| PLAC1 | -2.658369 |
| CASQ2 | -2.660241 |
| CAVIN3 | -2.661827 |
| ANLN | -2.662587 |
| SPHKAP | -2.668391 |
| IGSF5 | -2.672417 |
| SYNPO2L | -2.672782 |
| GPR22 | -2.683250 |
| SMYD1 | -2.687409 |
| SORCS3 | -2.687721 |
| LINC00881 | -2.692807 |
| HRH2 | -2.694184 |
| PEBP4 | -2.695043 |
| CDCA8 | -2.698342 |
| CEP55 | -2.708550 |
| SPX | -2.708569 |
| AMT | -2.719618 |
| DIRAS3 | -2.722534 |
| CDC45 | -2.726066 |
| POLE2 | -2.734335 |
| TRDN | -2.737878 |
| NMRK2 | -2.747681 |
| PIMREG | -2.749342 |
| EPN3 | -2.749571 |
| FPGT-TNNI3K | -2.753526 |
| REC114 | -2.761811 |
| SH3BGR | -2.764689 |
| MOG | -2.766072 |
| CSPG5 | -2.786076 |
| H4C3 | -2.794520 |
| SMIM1 | -2.796013 |
| SRPK3 | -2.800608 |
| SLC15A2 | -2.804699 |
| SLC38A3 | -2.806756 |
| ASF1B | -2.817701 |
| TNNT2 | -2.820532 |
| RAB9B | -2.823723 |
| EMC10 | -2.824767 |
| IMMP1L | -2.829254 |
| HMGB2 | -2.830279 |
| FMC1 | -2.830632 |
| LINC01456 | -2.832458 |
| NCAPH | -2.854564 |
| ENPP5 | -2.856968 |
| KIF2C | -2.860460 |
| CRIP1 | -2.865284 |
| VSTM2L | -2.866543 |
| LGALS3 | -2.871758 |
| LEFTY2 | -2.880727 |
| CSRP3 | -2.882775 |
| C11orf52 | -2.904686 |
| MCM5 | -2.908502 |
| NREP | -2.911058 |
| RXRG | -2.913305 |
| UBE2T | -2.922022 |
| HRC | -2.948080 |
| NEIL3 | -2.948272 |
| SGO1 | -2.953492 |
| PTGES3L | -2.953571 |
| AQP10 | -2.967106 |
| LINC01405 | -2.969873 |
| G0S2 | -2.979050 |
| FRMD3 | -2.990653 |
| TOP2A | -3.004569 |
| HOPX | -3.009609 |
| C1orf105 | -3.013779 |
| NUDT7 | -3.015060 |
| PANCR | -3.015240 |
| COL9A1 | -3.024658 |
| SPC24 | -3.025167 |
| ZWINT | -3.030731 |
| BBOX1-AS1 | -3.034916 |
| DHFR | -3.035134 |
| CRYM | -3.048275 |
| SELENOP | -3.060758 |
| KIF20A | -3.066232 |
| CAV3 | -3.066379 |
| GABRA4 | -3.068427 |
| CDCA3 | -3.086259 |
| NPPA | -3.091703 |
| SLC5A12 | -3.096242 |
| FGF13-AS1 | -3.097264 |
| PPP1R1C | -3.100553 |
| ITGB1BP2 | -3.103756 |
| AIF1L | -3.108962 |
| PLCB2 | -3.129927 |
| CALN1 | -3.145096 |
| TESC | -3.150083 |
| NUF2 | -3.151356 |
| SPSB4 | -3.155675 |
| LSMEM2 | -3.164595 |
| PPP1R1A | -3.171572 |
| KLHDC9 | -3.218902 |
| DMAC1 | -3.234254 |
| FAM133A | -3.237091 |
| CHCHD10 | -3.261912 |
| NDC80 | -3.269491 |
| FSD2 | -3.274605 |
| OIP5 | -3.282617 |
| FITM1 | -3.291142 |
| TRIM54 | -3.298866 |
| CENPU | -3.303800 |
| CDKN3 | -3.334427 |
| AURKB | -3.351708 |
| ATP6V1G2 | -3.357918 |
| DLGAP5 | -3.375682 |
| GPD1 | -3.377976 |
| SMPX | -3.395799 |
| LMOD2 | -3.403714 |
| HSPB3 | -3.409678 |
| MYH7 | -3.415903 |
| C1QL1 | -3.445765 |
| TNNI3 | -3.479622 |
| FABP3 | -3.492141 |
| MARCHF11 | -3.530975 |
| MB | -3.542870 |
| CD36 | -3.544471 |
| SLC35D3 | -3.553160 |
| LINC01182 | -3.561014 |
| LDHD | -3.576655 |
| LINC01611 | -3.581984 |
| MIR133A1HG | -3.586468 |
| ACTC1 | -3.599775 |
| MYLK-AS1 | -3.614126 |
| PCLAF | -3.618731 |
| GINS2 | -3.632645 |
| LDB3 | -3.633489 |
| GJD2 | -3.648797 |
| TNNI1 | -3.649594 |
| NAV2-AS2 | -3.659571 |
| SUSD2 | -3.664531 |
| RAD51AP1 | -3.668636 |
| CORIN | -3.695186 |
| CPNE5 | -3.696150 |
| HSPB7 | -3.772049 |
| NME5 | -3.772923 |
| MYL4 | -3.789321 |
| ACE2 | -3.792261 |
| FGF12 | -3.795245 |
| TROAP | -3.795809 |
| CCDC34 | -3.807975 |
| CKMT2 | -3.843017 |
| ODAM | -3.875695 |
| MYL7 | -3.935387 |
| ADPRHL1 | -3.938632 |
| S100A8 | -3.987699 |
| MAOB | -4.013483 |
| TNMD | -4.017589 |
| TMSB15A | -4.023837 |
| MSS51 | -4.049343 |
| CENPM | -4.064744 |
| TCAP | -4.067439 |
| PBK | -4.114213 |
| COX6A2 | -4.168300 |
| IRX4-AS1 | -4.282455 |
| TNNC1 | -4.285373 |
| LINC02502 | -4.298163 |
| FAM111B | -4.336571 |
| SPC25 | -4.366327 |
| FXYD1 | -4.430059 |
| ACTA1 | -4.549569 |
| HHATL | -4.724839 |
| METTL7B | -4.984910 |
| ALAS2 | -5.044219 |
| FBXL22 | -5.289780 |
| MYL2 | -5.499683 |
| KCNIP2 | -5.719563 |
| PGAM2 | -5.823109 |
[2]
16035 gene sets with size larger than 200 or smaller than 15 were filtered out from a total of 16746, the remaining 711 gene sets were used in this analysis. We used a stricter boundary to obtain more rigorous results. We selected the permutation number of 1000, which has a suitable running time for the program.
The Positive Phenotype (na_pos):
Table 3. Enrichment Plot of the Top 20 Gene Sets Ranked in the Positive(Virus) Phenotype
517 out of 711 gene sets are returned in the Virus (na_pos) sub-type. 421 gene sets are significant at FDR < 25%. 304 gene sets are significantly enriched at nominal p-value < 1%. 366 gene sets are significantly enriched at nominal p-value < 5%. The most related gene set in this sub-type according to the analysis is DEFENSE RESPONSE GOBP GO:0006952, with an enrichment score (ES) of 0.5994537 and a normalized enrichment score (NES) of 4.323445.
Figure 1. Profile of the Running ES Score & Positions of DEFENSE RESPONSE GOBP GO:0006952 on the Rank Ordered List
Figure 2. Random ES Distribution of DEFENSE RESPONSE GOBP GO:0006952
knitr::kable(DEFENSE_RESPONSE_GOBP, caption = 'Table 4. DEFENSE RESPONSE GOBP')
| NAME | RANK.IN.GENE.LIST | RANK.METRIC.SCORE | RUNNING.ES | CORE.ENRICHMENT |
|---|---|---|---|---|
| OAS2 | 2 | 7.149848 | 0.0245612 | Yes |
| OAS1 | 3 | 6.914038 | 0.0508740 | Yes |
| MX1 | 4 | 6.839104 | 0.0769017 | Yes |
| OAS3 | 6 | 6.040390 | 0.0985651 | Yes |
| IFI44L | 7 | 5.886140 | 0.1209661 | Yes |
| IFNB1 | 9 | 5.579821 | 0.1408767 | Yes |
| CXCL2 | 11 | 5.393316 | 0.1600776 | Yes |
| RSAD2 | 12 | 5.381730 | 0.1805589 | Yes |
| IFIT3 | 13 | 5.363579 | 0.2009711 | Yes |
| IL1B | 14 | 5.353070 | 0.2213434 | Yes |
| CCL7 | 15 | 5.291829 | 0.2414825 | Yes |
| MX2 | 16 | 5.179423 | 0.2611939 | Yes |
| CXCL1 | 20 | 4.990861 | 0.2762141 | Yes |
| PTAFR | 24 | 4.698314 | 0.2901210 | Yes |
| IRF7 | 30 | 4.489884 | 0.3005857 | Yes |
| IFIT2 | 40 | 4.073136 | 0.3041663 | Yes |
| ISG20 | 41 | 4.034635 | 0.3195210 | Yes |
| ISG15 | 43 | 3.987277 | 0.3333709 | Yes |
| CXCL3 | 51 | 3.824323 | 0.3386536 | Yes |
| CXCL8 | 56 | 3.764355 | 0.3476816 | Yes |
| SAA1 | 58 | 3.753236 | 0.3606409 | Yes |
| IRF8 | 66 | 3.652257 | 0.3652688 | Yes |
| MICB | 71 | 3.587570 | 0.3736240 | Yes |
| SERPINE1 | 73 | 3.556188 | 0.3858333 | Yes |
| PTX3 | 75 | 3.554543 | 0.3980364 | Yes |
| CXCR1 | 80 | 3.476321 | 0.4059682 | Yes |
| BST2 | 86 | 3.420476 | 0.4123630 | Yes |
| TRIM14 | 91 | 3.388913 | 0.4199622 | Yes |
| IFITM1 | 93 | 3.349915 | 0.4313865 | Yes |
| DDX58 | 98 | 3.283058 | 0.4385829 | Yes |
| IFIH1 | 100 | 3.261873 | 0.4496721 | Yes |
| IFI6 | 103 | 3.245873 | 0.4593759 | Yes |
| TNFSF4 | 108 | 3.194547 | 0.4662354 | Yes |
| CD83 | 112 | 3.173820 | 0.4743406 | Yes |
| NFKB2 | 123 | 3.074822 | 0.4727974 | Yes |
| IL12A | 124 | 3.074159 | 0.4844968 | Yes |
| SAMHD1 | 126 | 3.052257 | 0.4947883 | Yes |
| RELB | 131 | 3.007213 | 0.5009348 | Yes |
| IL6 | 138 | 2.982850 | 0.5043396 | Yes |
| TLR4 | 140 | 2.977475 | 0.5143465 | Yes |
| TNFRSF6B | 141 | 2.973553 | 0.5256630 | Yes |
| GCH1 | 148 | 2.930393 | 0.5288683 | Yes |
| FOS | 149 | 2.924209 | 0.5399969 | Yes |
| IFIT1 | 153 | 2.897333 | 0.5470498 | Yes |
| ICAM1 | 161 | 2.844774 | 0.5486047 | Yes |
| APOL3 | 169 | 2.797154 | 0.5499783 | Yes |
| FOSL1 | 172 | 2.786567 | 0.5579342 | Yes |
| ADGRE5 | 191 | 2.699674 | 0.5443672 | Yes |
| CCL2 | 193 | 2.692769 | 0.5532907 | Yes |
| SP100 | 199 | 2.676217 | 0.5568531 | Yes |
| PMAIP1 | 209 | 2.637589 | 0.5549704 | Yes |
| TNFRSF10D | 211 | 2.620613 | 0.5636192 | Yes |
| F2RL1 | 218 | 2.589487 | 0.5655270 | Yes |
| LOXL3 | 231 | 2.511423 | 0.5591907 | Yes |
| CXCL6 | 258 | 2.410656 | 0.5339279 | Yes |
| TNFRSF1B | 259 | 2.408509 | 0.5430939 | Yes |
| HLA-E | 262 | 2.405630 | 0.5496001 | Yes |
| INHBA | 268 | 2.383219 | 0.5520474 | Yes |
| IRF1 | 269 | 2.379943 | 0.5611048 | Yes |
| APOL1 | 270 | 2.379876 | 0.5701619 | Yes |
| ULBP2 | 276 | 2.358103 | 0.5725136 | Yes |
| ELF3 | 279 | 2.340596 | 0.5787722 | Yes |
| CD44 | 280 | 2.340378 | 0.5876790 | Yes |
| TRIM38 | 282 | 2.333957 | 0.5952369 | Yes |
| CFB | 293 | 2.294208 | 0.5907229 | Yes |
| TRIM25 | 294 | 2.294127 | 0.5994537 | Yes |
| TRIM22 | 381 | 2.055730 | 0.4933699 | No |
| PIK3CD | 386 | 2.048266 | 0.4958670 | No |
| HRH1 | 392 | 2.039099 | 0.4970047 | No |
| EGR1 | 393 | 2.037634 | 0.5047594 | No |
| MYD88 | 403 | 2.019954 | 0.5005262 | No |
| CAMK2A | 549 | -2.271184 | 0.3171166 | No |
| EPHX2 | 588 | -2.384289 | 0.2758595 | No |
| HMGB2 | 702 | -2.830279 | 0.1369618 | No |
| ODAM | 805 | -3.875695 | 0.0166122 | No |
| S100A8 | 808 | -3.987699 | 0.0291392 | No |
Table 5. Enrichment Plot of the Top 20 Gene Sets Ranked in the negative(Mock) Phenotype
194 out of 711 gene sets are returned in the Mock (na_neg) sub-type. 98 gene sets of them are significantly enriched at FDR < 25%. 69 gene sets of them are significantly enriched at nominal p-value < 1%. 89 gene sets of them are significantly enriched at nominal p-value < 5%. The most related gene set in this sub-type according to the analysis is CELL CYCLE REACTOME R-HSA-1640170.1, with an enrichment score (ES) of -0.56024605 and a normalized enrichment score (NES) of -3.6521144.
Figure 3. Profile of the Running ES Score & Positions of CELL CYCLE REACTOME R-HSA-1640170.1 on the Rank Ordered List
Figure 4. Random ES Distribution of CELL CYCLE REACTOME R-HSA-1640170.1
knitr::kable(CELL_CYCLE_REACTOME, caption = 'Table 6. CELL CYCLE REACTOME')
| NAME | RANK.IN.GENE.LIST | RANK.METRIC.SCORE | RUNNING.ES | CORE.ENRICHMENT |
|---|---|---|---|---|
| CDC14A | 167 | 2.798065 | -0.1873640 | No |
| PLK1 | 409 | -2.000453 | -0.4754434 | No |
| GTSE1 | 465 | -2.089318 | -0.5270098 | No |
| CDKN2C | 468 | -2.096007 | -0.5113444 | No |
| ANAPC16 | 475 | -2.104280 | -0.5006769 | No |
| CDC20 | 523 | -2.200800 | -0.5411358 | Yes |
| CDC6 | 528 | -2.216078 | -0.5269628 | Yes |
| PLK4 | 530 | -2.221475 | -0.5089405 | Yes |
| TK1 | 566 | -2.320188 | -0.5331537 | Yes |
| CDCA5 | 567 | -2.322462 | -0.5129871 | Yes |
| FOXM1 | 575 | -2.340321 | -0.5015374 | Yes |
| UBE2C | 580 | -2.349332 | -0.4862072 | Yes |
| RPA3 | 585 | -2.365246 | -0.4707388 | Yes |
| CENPH | 595 | -2.395726 | -0.4613429 | Yes |
| HJURP | 614 | -2.451450 | -0.4628700 | Yes |
| CCNB2 | 623 | -2.500282 | -0.4512988 | Yes |
| CDK1 | 628 | -2.528634 | -0.4344116 | Yes |
| RMI2 | 635 | -2.542336 | -0.4199404 | Yes |
| NEK2 | 637 | -2.561090 | -0.3989692 | Yes |
| PKMYT1 | 643 | -2.575518 | -0.3829424 | Yes |
| RRM2 | 646 | -2.581340 | -0.3630628 | Yes |
| BIRC5 | 649 | -2.603424 | -0.3429914 | Yes |
| UBE2E1 | 656 | -2.633303 | -0.3277302 | Yes |
| CDCA8 | 676 | -2.698342 | -0.3283809 | Yes |
| CDC45 | 681 | -2.726066 | -0.3097794 | Yes |
| POLE2 | 682 | -2.734335 | -0.2860364 | Yes |
| NCAPH | 705 | -2.854564 | -0.2891329 | Yes |
| KIF2C | 707 | -2.860460 | -0.2655621 | Yes |
| MCM5 | 714 | -2.908502 | -0.2479114 | Yes |
| TOP2A | 726 | -3.004569 | -0.2357636 | Yes |
| SPC24 | 732 | -3.025167 | -0.2158324 | Yes |
| ZWINT | 733 | -3.030731 | -0.1895157 | Yes |
| DHFR | 735 | -3.035134 | -0.1644282 | Yes |
| KIF20A | 738 | -3.066232 | -0.1403381 | Yes |
| NUF2 | 751 | -3.151356 | -0.1281831 | Yes |
| NDC80 | 759 | -3.269491 | -0.1086652 | Yes |
| OIP5 | 761 | -3.282617 | -0.0814288 | Yes |
| CENPU | 764 | -3.303800 | -0.0552758 | Yes |
| AURKB | 766 | -3.351708 | -0.0274395 | Yes |
| GINS2 | 788 | -3.632645 | -0.0225122 | Yes |
| CENPM | 813 | -4.064744 | -0.0176351 | Yes |
| SPC25 | 821 | -4.366327 | 0.0114069 | Yes |
[4]
These results do not have a threshold which is a cut-off according to p-value, so the returned gene sets are slightly different. It is a straightforward comparison. Because they are both imported from the same normalized data.
Visualizing the results from the non-thresholded gene set enrichment analysis in Cytoscape by Using Enrichment Map and AutoAnnotate.
Figure 5. Pre-Analysis Parameters Used for the GSEA Analysis
Figure 6. Overview of the Network
Figure 7. Pre-Annotation Parameters
Figure 8. Annotation Parameters
Figure 9. Mock vs. Virus Enrichment Map. Red: Virus group; blue: Mock group. The virus group coming from in vitro hiPSC-CMs infected with SARS-CoV-2 while the Mock group are in vitro hiPSC-CMs not infected with SARS-CoV-2
The major themes that fit with the model include blood circulation heart,actin contraction filament, organism organelle organization, mitotic cycle sister, signaling cellular interferon, apoptotic programmed death, naba factor matrisome, positive cell proliferation, response biotic virus, taxis migration chemotaxis, programmed cell death, component movement migration, hallmark allograft rejection, activation involved neutrophil, viral life multi, negative regulation cellular, regulation metabolic positive, inflammation response stress, vasculature development, protein localization transport, transcription regulation biosynthetic, transmembrane transporter activity.
There are also novel pathways and themes that do not fit with the model: epithelial mesenchymal, myogenesis, tnfa signaling, inflammatory response, hypoxia, muscel development tissue, extracellular organization matrix, estrogen response, oxidative phosphorylation, e2f targets, p53 pathway, interferon gamma alpha, uv response, kras signaling, g2m checkpoint and il2 stat5.
Figure 10. Mock vs. Virus Collapsed Theme Network
[10]
Yes, the enrichment results support conclusions and mechanisms discussed in the original paper at some point.
The original paper concluded that SARS-CoV-2 infection (Virus group) induces significant transcriptional changes within hiPSC-CMs(human iPSC cardiomyocytes in vitro) in gene pathways related to cellular metabolism and immune response.
In the Virus group, considerable amount of gene sets and themes are related to reacting to abnormality according to the positive phenotype enrichment plot (Table 3.) and the enrichment map (Figure 9.), such as virus response, inflammatory response, defense response, mass of apoptosis, etc. There are also many themes related to metabolic, transcriptional and cellular pathways.
But we didn’t see any significant themes about normal heart activities as those shown in the Mock group. So we conclude that the SARS-CoV-2 infection might lead to immune response and affect normal heart activity in metabolic, transcriptional and cellular pathways, such as functional alterations, transcriptional changes, apoptosis mentioned in the result of original paper.
In the enrichment analysis, the CM-upregulated transcriptome showed significantly high enrichment in the gene set GSE150392 (the original data for this assignment) down-regulated by SARS-CoV-2 infection in cardiomyocytes. [11]
Figure S1. Table of Gene Sets From Kumar et, al.
[11]
They observed that SARS-CoV-2 infection creates precise and ordered disruptions to the myofibrillar structure and dissolution of the cardiac contractile machinery, which would lead to cardiac functional collapse. [12]
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